ID   A0A0N5C564_STREA        Unreviewed;      1050 AA.
AC   A0A0N5C564;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   SubName: Full=ShKT domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001309300.1};
OS   Strongyloides papillosus (Intestinal threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001309300.1};
RN   [1] {ECO:0000313|WBParaSite:SPAL_0001309300.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01005}.
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DR   AlphaFoldDB; A0A0N5C564; -.
DR   STRING; 174720.A0A0N5C564; -.
DR   WBParaSite; SPAL_0001309300.1; SPAL_0001309300.1; SPAL_0001309300.
DR   Proteomes; UP000046392; Unplaced.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd09823; peroxinectin_like; 1.
DR   Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR   InterPro; IPR019791; Haem_peroxidase_animal.
DR   InterPro; IPR010255; Haem_peroxidase_sf.
DR   InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR   InterPro; IPR003582; ShKT_dom.
DR   PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR   PANTHER; PTHR11475:SF85; SHKT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03098; An_peroxidase; 1.
DR   Pfam; PF01549; ShK; 1.
DR   PRINTS; PR00457; ANPEROXIDASE.
DR   SMART; SM00254; ShKT; 1.
DR   SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR   PROSITE; PS50292; PEROXIDASE_3; 1.
DR   PROSITE; PS51670; SHKT; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..1050
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005895372"
FT   DOMAIN          40..79
FT                   /note="ShKT"
FT                   /evidence="ECO:0000259|PROSITE:PS51670"
FT   REGION          203..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         822
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ   SEQUENCE   1050 AA;  117704 MW;  604684B8D6836C24 CRC64;
     MSIPLGGMRR WIIELIIIGV LLLIIAESKD DNPITKNFKC RRNGCCDQHE WCRFWASAGE
     CMVNKKWMEE NCQLACNACK RLNPKVVPTK KAASKIPIPR ALLLSKPIAS THIASKPPTL
     LNEVNKKIIF VKSPSQGTLK IPASNTRFIN NKPQTISRLQ VVTRKPITIL KQPPLSRVAT
     TPQISNVIKP LQHPLRIPSK PSTKPFDNAQ RPNNNNHFMP SHTPRILEKP KIVTTTVQPP
     PKQDSFNGTL TTPHNKIIIS GSIDDVPSSA VSTKIITHEV TDKSILSQNN PQITPILPID
     VVKNESLSSS SLSLKNDTIL NKEDSHLLLN DNIDKILLNN TFILPIDRPN SQKGENLGIV
     QPKSEAKRPT HKIGNFKSQT RTFLQSISST PPTLHLPTPS HIVFQTKETV PLKTTLRPVI
     QTMKIISTSL RQTTVSPINK SKNVLGSKIE LCRRLLSDPT NIAVNIKKNN LVFTAEDNDG
     RRTLSLDDVI RSNLANACTP RLDDSNCERN LCYNLYFRTM DGTCNNLEKP LQGASYRPYN
     RLLPPEYDDG LGAPVSSIKI NRPSPREINR NLLSSQAIVH ADDYNSLLMQ FGQFISHDMA
     KTTLVPSSKC PGCSNIEGRC MAIKLSANET NKNFLREGCI KVSRSSSICG SGRTKPRQQL
     NENTGYIDGS PIYGSSVDDL HKFRQGKTGF LKLSTFMGQR TLPFDQSRCK NDKNCNVIFI
     AGDSRVNLFI GLSSIHILFT REHNRIAGIF KRINPQWSDE RVFQETRKLV GAQIQAIVYR
     EYLPKILGSA FMTAIGPYKG YNPNVDATIV NEFTSSAFRY GHGMIQETFP RLGENFRNIS
     FGSYNFVKGT LNSQMLVKQG GIDPVLRGMM LTKLKRPQRL TSIITENMFE STDLGSINIQ
     RGRDHGLPPY NKFRDLCGLN KARTFEELSK EILSPFTRSK LQKIYGSVDT VDLFVGAILE
     DPVLHGLIGP TITCIIGPQF KRTRDGDRFY YENPGIFTPQ QLKEIRKSSF SRILCDNGDN
     INLVTKEAFR VSNLTPCTQI PKMDLSKWKE
//