ID A0A0N5CGZ8_STREA Unreviewed; 936 AA.
AC A0A0N5CGZ8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ras-GEF domain-containing protein {ECO:0000313|WBParaSite:SPAL_0001712300.1};
OS Strongyloides papillosus (Intestinal threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=174720 {ECO:0000313|Proteomes:UP000046392, ECO:0000313|WBParaSite:SPAL_0001712300.1};
RN [1] {ECO:0000313|WBParaSite:SPAL_0001712300.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
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DR AlphaFoldDB; A0A0N5CGZ8; -.
DR STRING; 174720.A0A0N5CGZ8; -.
DR WBParaSite; SPAL_0001712300.1; SPAL_0001712300.1; SPAL_0001712300.
DR Proteomes; UP000046392; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 550..669
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 701..932
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 165..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 108911 MW; E4DF62CC91242539 CRC64;
MTDGISYIVI ESITKLLKAI DSKKFDTINN IFNETISCLI NINFDNENEK EKYSKLLGDL
IKWWDSLSIK ICCDDSFIIS DDDISIGKKL LFDIQKYVTV NSWEVSVDDK EEEEKCYGGG
VISDMIVYSL PMLEKTSNSD EFCSLMKNLM NRQVEVFKPN FQIVEGESDD DGYEEEKCEE
ESETRKEQHG SRTTEEEITK TPDGREIRST KTRIVNSSRT SKNVTVRTFG NGQNNIRRNF
FDVNRSHHED SDEEFFETFK KPTFGKRSTF KDSGNSFFND KKVLVFNGID DSKFLSPNSL
GRLDDNPITD ESKNLSDSGE EQSNELQKIK KVDHSSATLQ VVEKTKKTNG KLKFNATAHK
LDTKQLSGQQ KEIYDGDELI RKEGDGCYEE NTTMGTGDIN PEALINLGTV NRFGLHKSKE
FECGNYDNNG SYIKGLTMTS YLIVNESINN HEEQFRKKLQ FEFRNNCALK VEESKGNDNK
INLNQLLELS DFNEMDKEFD KKLSDMKKFK EFGEIYHGIL SLPEDLSLFE QDDVKDYLVF
LTKTNDTGNT SEICRGGPKN ALIVYATQND ASLLYKEAFL TTYRTFISSL DVIRYLLYRF
QYMNNNYNTK QNSNAHSTIS VIIRIIQNLS ITEMSEEILS LIKELYITLY NNYEVQFLKI
LRKIIFTNIT TFHKSKNNNI LPKQVHCMLN GQRVKEFLNL RSMKLAQEIT IISSKLFHNV
KELELLWWSI DQSNSHSMNL RRLTNNFNFI SYWCRSLILM SNEQKTREKV FNKFLKISKY
LRQFGDLNSY LAIIAALDSG PVNRLSWNKA INDGMKEHKL IMSSSYSFKN YRQLFSQCKP
PCVPYIGIIL QDLTFIFNGT VEKLSDMEYN GINYINFVKC FKQFTILESI RKLKMWDYSF
ETSEDYKNFL NNFVEHYSEE ECWMRSEMIK PRQSKH
//
