ID A0A0N5CMW1_THECL Unreviewed; 1484 AA.
AC A0A0N5CMW1;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN ORFNames=TCLT_LOCUS1503 {ECO:0000313|EMBL:VDM96983.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000150201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000150201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM96983.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; UYYF01000198; VDM96983.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CMW1; -.
DR WBParaSite; TCLT_0000150201-mRNA-1; TCLT_0000150201-mRNA-1; TCLT_0000150201.
DR OMA; WWFNVIL; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF111; VALYL-TRNA SYNTHETASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1068..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1145..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1188..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1241..1262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1268..1285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1319..1344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..670
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 715..863
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT COILED 924..951
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1484 AA; 171989 MW; 1C6E8470E4477546 CRC64;
MISRSRFKYV AHMHSYYAGR GSSFQARTAN TSFDIDVVTN SYGKKARHDT VVIRSKKISP
EVYRMVLPPP NITGNLHIGH ALTVTVEDAI CRYRRLRGQQ VTWYPGFDHA GIATQVVVET
MLWNKMKLRR HEVTQSYFLE LCRKWKQEYK NIGRTFVRFR RVNDISKQLK ALGATLDWHN
VYYTLDDKFS EAVKIAFCQL YDKGIIFNDL RMINWCPTLR SSISDQEVNI VDVGKSKSLG
CVMYGCQRNL TDVGIMHLIR YELLSGDSFC GNNYLEVGTT RPETLFDDIA LAVNPNDERY
AKHIGSHVRH PFFPNRLLPV VADLLVNINK GTGVLKVAPT HGLIDFQIAK KHKDFINDED
LNRSCIDESG RLINTSDFDG IDRFEARRKI IDKLSACNKY GGTIPYPEHQ LKICSRTGDV
IEPMVKKQWF MNCVDMNNRA LEAIENGVIT IAPKSMQIHL ENWLSKKEPW CLSRQLDWGQ
QIPAFRVDPN SEWIVALDKV EAQRACGRRI TEIDLEQEKD VLDTWFCSAL IPIVLSGWPK
KEIKYVPLTM LETGFDIAGF WVARMITVCH SLTGYWPFSQ VLLHGLVRDE NGKKMSKSIG
NIIDPMDVID GISIQKMLER LNESNISEVE KKTASISLQS RFPKGIRRCG PDALRFALLR
HDVTATDINI DIVQTAEEGL RFCNKLWNLC AYAKKLWESC REEALDDLSV HRIEDRWIQS
RLESSLMVMT KKMESNSLHL AFNALHKFFC NDLCDVYIET TKKALWRKEH LRLKVIAENL
HDIIEKSLVH LSIFMPFISE YLFDNIKRNE EQSVYNYLSE RHLKFYKIDK KLEEDMSFVL
ELITAVRSIR SHFHIAAKNP LKVSCQTESC DLKNFESMIY ELCNVTLRMT DPEKCNNHYI
PFPLRGYSTE INVFIEDTFG SLIKTELLRR LQKAQKRKNQ FLHRVEKHQK LAKSVVKNNS
VECHERKIFQ AKAVVNGMEE EILKLENLIK QSMDIKGNFK DLLLAVVCVF HITIAPYTKV
EESFNVQAYD HHKFPGVVPR TFTGALALSA PLLPVVHIFE YFNISKYWML YGMRLVLGLS
VLFAFIEFIK RIDKQFGQLS GDFLRLLTAT QFHFMFYCSR PLPNIFALYG GKIFWTYQKI
LDRHWICAAG IATVFTLLFR CELILFYACI FFYPILTRKF SLFSWNGAVV YCCFVAFLAL
GISIPIDSYL WRRWLWPEGE VWWFNVILNR SKEYGVLPFS WYFYSAIPRA LSVSCVFVPI
GLISDRRLAP IVTPVLLYVL LYSFLPHKEL RFIIYAIPIL NVSVAVCYAR IWISRRKSLF
RMLLAVAVLV NLLLNIICTA AFLFASSKNY PGAEALVSLQ HMQRSDHNKP VSVYIDTYAA
QTGVCRFLQL YDTWEYNKTE NLKSSQMERF DFLILGSYTE SDITNFTTLQ FHSTHQILHS
VKAFQGIELQ RLYLLPYYWP VVKFRTQLVV MEKILIVTVV HVVV
//