ID A0A0N5CWX7_THECL Unreviewed; 629 AA.
AC A0A0N5CWX7;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Moesin/ezrin/radixin homolog 1 {ECO:0000313|WBParaSite:TCLT_0000487001-mRNA-1};
GN ORFNames=TCLT_LOCUS4859 {ECO:0000313|EMBL:VDN02033.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000487001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000487001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02033.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; UYYF01004307; VDN02033.1; -; Genomic_DNA.
DR STRING; 103827.A0A0N5CWX7; -.
DR WBParaSite; TCLT_0000487001-mRNA-1; TCLT_0000487001-mRNA-1; TCLT_0000487001.
DR OMA; QDEMRMA; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17097; FERM_F1_ERM_like; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF39; MOESIN_EZRIN_RADIXIN HOMOLOG 2; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PIRSF; PIRSF002305; ERM; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776}.
FT DOMAIN 18..305
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT COILED 341..389
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 557..598
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 629 AA; 73156 MW; 40CCB0CC5BEA193E CRC64;
MFISSMGFFS SGSSGKYLSV KVSTMDADLE KISVEPDCSG RHLFDTVCRI IGLREIWFFG
LQFVNRKGIP CWLQMDKKIN KQEVPKQEDG SIHFIFLVKF YPEDVEEELI QDITRHLFFL
QIKQSIISMQ LYCSAEASVL LASYAVQAIQ GDCTECSELK LSEFLPECVI KQYDMTPQMW
EERIKRWWIN NSGQSREDAE MEYLRVAQDL EMYGIQYYPI CNSKETDLTL GVSAQGIGIY
KESNRITPRP FFSWSEIKNI SFKNKVFSMR TMDKSTITFR AKDMSINMSI LDLCVGTHNL
YLRRRQPDLL EVQQMKAQAK EQRIRRIIAL LVSISMHQLI LQQEQNRMSR EKEQRIQAEA
ERDQYKNEVA AISEQLHNVK EAMKKTQENA HLMAEKARVS EEEALVLSKR ASEAEAECQR
MKLSQIKAEE TKMSLERKAR NAELWAHRLM HETERHNYNQ YFCRAHLCDS EPSWPQDCLS
AYAVPVSQPS SHQRLISLSS NGDAGYVQYV DDELNFSASV TPTVKTQPFL RKQTTLNFPP
PDPSSNQIIP NDLLSLRTEI EKSRADYNEK KKSLQEKMNE FRDEMEILKV ENRQSEHDRI
HIANIQMGMD KYSTLRKVIF IFTGFNKPI
//
