ID A0A0N5CXH8_THECL Unreviewed; 462 AA.
AC A0A0N5CXH8;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=TGF_BETA_2 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000510501-mRNA-1};
GN ORFNames=TCLT_LOCUS5094 {ECO:0000313|EMBL:VDN02298.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000510501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000510501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02298.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; UYYF01004320; VDN02298.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5CXH8; -.
DR STRING; 103827.A0A0N5CXH8; -.
DR WBParaSite; TCLT_0000510501-mRNA-1; TCLT_0000510501-mRNA-1; TCLT_0000510501.
DR OMA; IETSFCK; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13763; TGF_beta_BMP3_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF280; TGF_BETA_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..462
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035041900"
FT DOMAIN 338..462
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 462 AA; 53063 MW; 09EAA3E41F3068F3 CRC64;
MNDIIFFDTV LLSSLLYIGF STSTVLQPTK EQIAILQTTF KNLLDLEHLP SNARQPALRI
ENAASKYMRR LFNQYNADIN DQNNLHGNII RSINPTVEIL FGEELLIFKL NRIKPTEQIV
RAELHYNIHP KHRSVWKHVK NIVKAHAFLQ NNGKKQTVQL NPSSASDFLL NFDMTELVLK
AISANQSIIA VKFLRNGKKM KCSGMFKHNT PFLLVYTKES FLINAINHSF KISADAFHQL
SSGLKKRSKR MSPYYEYSAK EKQDANDSSN TWEAQSVQQL KTYRELGPRI LRDRKQDRRL
QMRKQKKIRG AFRNDPMMGF GVKKKFTKII TPSPSSVVQE KAEDVTLVLL PGQTFSSQSC
RKQKLNVRFR DIGWEHWIIA PTSFEAHYCS GTCPFPLRKE MNPSNHAIVQ SIIYQLGLNP
DIPNVCCAPD KMDSLSLLYY DEVDNVVLKN YPRMTVTSCA CL
//
