ID   A0A0N5CXX2_THECL        Unreviewed;       671 AA.
AC   A0A0N5CXX2;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000527301-mRNA-1};
GN   ORFNames=TCLT_LOCUS5262 {ECO:0000313|EMBL:VDN02484.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000527301-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0000527301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN02484.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYYF01004330; VDN02484.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N5CXX2; -.
DR   STRING; 103827.A0A0N5CXX2; -.
DR   WBParaSite; TCLT_0000527301-mRNA-1; TCLT_0000527301-mRNA-1; TCLT_0000527301.
DR   OMA; FITYYDW; -.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23175:SF23; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..671
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035110636"
FT   DOMAIN          1..183
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          262..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  74852 MW;  06AA5E71AB43D087 CRC64;
     MLQMVPLIIR LCVKVVESHG MDTVGIYRIP GNTAAVNALK ETLNGELTEI DLADPKWNDV
     NVVSSLLKMF LRKLPEPLLT DKLYPFFIDA NRITSHAQRL RKLRNLVHKL PLAHYETLKY
     LMGHLKEVVA HSDINKMETR NLALMFGPSI VRPSDDNMAT MVTHMSDQCK IVEAFITYHN
     WMFGEICEDD VPPQVAPSDS TVSSGNISGV GSNLTSSIGD YDAVIMTTSF NDMHNLIRRA
     NEVEATAMMD AQKYGKIKNI LNVRRNSKRD KRKKVRDHSA HAASNTPSSS CNMRKLFKAS
     ASQPTATASF GSDEHTLARV YQERDIDAEI ALRKQQRTPT RPMLQHSGAS SSADHSCSRS
     RSSATHDVTP PLSLNSSREN SDEADEMRRR RQKEMYSARR IFIAGTDADL NDNVDLDDLM
     SHSRHLNLAS SPALDVLSAE TREKIRRLQQ LQGWATTALE RRDAEGATNK KYPPVQKTQT
     EVKLILPIKT ATEDFSSTDA LSLTSDYSTT SSAPLTIPVT VSCIDHLTAA SSDYASSDVS
     PNTRNVSTSP SQVDLEVLGL NSSPTVSDHF KHSQGEEMQM SSSTTENCYK SLENVSLEPL
     LITPTKHSEN QSKGGFLGYK EMCKMSVPQA HEISFSNGSK VKARMKLNSR RELWRRHTLS
     DMDIVKQVNF Y
//