ID A0A0N5CY13_THECL Unreviewed; 491 AA.
AC A0A0N5CY13;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=DH domain-containing protein {ECO:0000313|WBParaSite:TCLT_0000531601-mRNA-1};
GN ORFNames=TCLT_LOCUS5305 {ECO:0000313|EMBL:VDN02532.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000531601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000531601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN02532.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; UYYF01004332; VDN02532.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5CY13; -.
DR STRING; 103827.A0A0N5CY13; -.
DR WBParaSite; TCLT_0000531601-mRNA-1; TCLT_0000531601-mRNA-1; TCLT_0000531601.
DR OMA; FWVAQIE; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..235
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 491 AA; 55733 MW; 1E6AE3B50A7161EE CRC64;
MPSNSITRSK PEVFPVCDQY STVATKSKKL AKVCVFLVII VIAIPIHVVA HFQELLDTER
KYCHDLASCY KVFTQGLREI ITIELKKKLF LNCKELISVS NSVHNALTQQ SPGDVFVDKI
PMLRAYVEFC SKQQAALETL HELEQNSASF RQVNFYFISM KLVISNPKIS YRSCCMKTNG
LNLNYFLLLP MSRITRYPLI FEKLVKCTSL DDPKRKNLEK AHESLKSLCA EINDVINAMD
NSSMLIWAQQ HIHCDAIQPP IVFLSSTRKV GPRCLLHSGA LQKQLNGKTL VALLFNDFLM
LTTPLDPIEQ LEEFRISKVS EVQLNLYKMP LLLENAGVSQ TKEMDDCSFE VHAGEFSVVL
RAPNRNARVF WVAQIEKAIT EYRNQSLTLE TPSVAGDISE QGRLFVELVC IRNVDNALRL
LGAQSVFCKF RIGQSSKCAE VDMNRKEHLC TTQLSIYKST LDSLFEISIF LNRIYSPDLC
VGMLLLSDYC L
//
