ID A0A0N5D473_THECL Unreviewed; 513 AA.
AC A0A0N5D473;
DT 09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT 09-DEC-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=TCLT_LOCUS7748 {ECO:0000313|EMBL:VDN05232.1};
OS Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0000775901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TCLT_0000775901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN05232.1, ECO:0000313|Proteomes:UP000276776}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; UYYF01004541; VDN05232.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0N5D473; -.
DR STRING; 103827.A0A0N5D473; -.
DR WBParaSite; TCLT_0000775901-mRNA-1; TCLT_0000775901-mRNA-1; TCLT_0000775901.
DR OMA; GGNEHIQ; -.
DR Proteomes; UP000046394; Unplaced.
DR Proteomes; UP000276776; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF28; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 4.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..52
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 114..156
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 156..183
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 283..325
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 325..367
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 56205 MW; 07BADCC1A93AE206 CRC64;
MTESRQTQYK NMGKDSEALR KNRAENIISI RKDKREETLS KRRNIPFESL ESDDASTSAG
SAFLNGAFNR TTLEDIVKRA NSQDQEIQLS AVQQARKLLS SDRNPPIDDL IASGILPILV
HCLSSSNVTL QFEAAWALTN IASGTSQQTQ AVVQAGAVPL FLELLSSGNM NVCEQAVWAL
GNIIGDGPHF RDYCIQLGIV EPLLKFITPG IPIGFLRNVT WVIVNLCRSK DPPPSPEIVQ
TLLPALAALI SHVDQNILVD TVWALSYLTD GGNEQIQMVI NSGVVTNLVP LLAHPEIKVQ
TAALRAVGNI VTGTDEQTQL VLDCGVLQQM PALLTHQKEK INKEAVWFLS NITAGNQAQV
QAVIDAGLIP MIIHLLQKGD FQTQKEAAWA VSNVTISGRA DQVEYMISQN VIPPFCALLS
IRDPQIVQVV LDGVNNILKM AGPRSEAVCT MIEECGGLDK IEHLQNHESE EIYKLAYEII
DNYFSENGDD GIAGDHFFES SQQNVPSEGF SFQ
//
