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Database: UniProt
Entry: A0A0N5DB33_THECL
LinkDB: A0A0N5DB33_THECL
Original site: A0A0N5DB33_THECL 
ID   A0A0N5DB33_THECL        Unreviewed;       652 AA.
AC   A0A0N5DB33;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   12-APR-2017, entry version 6.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0001039501-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0001039501-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:TCLT_0001039501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; TCLT_0001039501-mRNA-1; TCLT_0001039501-mRNA-1; TCLT_0001039501.
DR   Proteomes; UP000046394; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000046394};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046394};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    303    328       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    349    374       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    472    495       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    516    535       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    563    582       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   652 AA;  74491 MW;  E8DFD3E29C866937 CRC64;
     MILLISTYGP EFRRSRIIRS FTDCKVESAS HEKEARMQLT DAQQGISGPF VLDGEIYGKI
     RASTIASIES EITDKKDFKE VSFLAGTIHR NYAQSFERIL WRWCLGNVFV RMFDLQDLDH
     NFRAKVYSYP NTVSERKIMK EKLTARIEDM KAVLERSFQH RDKVLQATAQ NHGTWFIKYL
     NASSSITGDS QDICKPFVVL KMKATFSALN CFNFDVTQRC LIAEGWAPTE ELYLIKLALE
     RGMEVSGSII APVINEMTTT SVPPTFNKVN KFTRSYQNIV DAYGVANYQE INPTPWTIIT
     FPFIFAIMFG DAGHGLIMFF LALILIIYEK RFIAAKIKDE IFNIFFGGRY VILLMGLFSA
     LYTTIFIPNL SIFLEAAGKT LTSQEPSLQK DLNGSGDLTL PPGYAFEHEK VSAKFMYSKK
     FFLKCNITFK DSFIMHVNKY AVDNGPYPFG VDPVWSISVN KLNYLNPLKM KMSVIVGISQ
     MTFGLALALL NHMYATRKKL FQIKSGYSFR LDPSTALPRF YLCLPLHTGL ISFAFKTKHE
     SDKQLRFQII TKWIMYYVWP QFIFGYFYPS SNCAPTLLIG LINMFMMKSR QAGFVDASVG
     NCSEYLQAIK NQDCTTSRIS VECSNAVKNC QPYAECALNQ WYPNQYPQNG FN
//
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