ID   A0A0N5DB70_THECL        Unreviewed;       338 AA.
AC   A0A0N5DB70;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Peptidase A1 domain-containing protein {ECO:0000313|WBParaSite:TCLT_0001043201-mRNA-1};
GN   ORFNames=TCLT_LOCUS10421 {ECO:0000313|EMBL:VDN08110.1};
OS   Thelazia callipaeda (Oriental eyeworm) (Parasitic nematode).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Thelazioidea; Thelaziidae; Thelazia.
OX   NCBI_TaxID=103827 {ECO:0000313|Proteomes:UP000046394, ECO:0000313|WBParaSite:TCLT_0001043201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TCLT_0001043201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN08110.1, ECO:0000313|Proteomes:UP000276776}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
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DR   EMBL; UYYF01005101; VDN08110.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0N5DB70; -.
DR   STRING; 103827.A0A0N5DB70; -.
DR   WBParaSite; TCLT_0001043201-mRNA-1; TCLT_0001043201-mRNA-1; TCLT_0001043201.
DR   Proteomes; UP000046394; Unplaced.
DR   Proteomes; UP000276776; Unassembled WGS sequence.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   Pfam; PF00026; Asp; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276776};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..338
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5035042147"
FT   DOMAIN          41..338
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
SQ   SEQUENCE   338 AA;  38382 MW;  328947FBD9F70EDF CRC64;
     MTVAELFNWL CVTFALVSVT HCEYRIKLDA IYNAFQQNVG FSARIWIGNS NKALNVLLDT
     TTPLLWVAGS ECRQFFEIQS CTSKRGYLSS ESTRYRANSP SKTFTFSSEE QYLIASQVSN
     NITIELTSRE KLKFVNSVFN IPEYIIWSRW TTDYEKLDGV LGLVFTNISS NFTDNPIKQV
     IQKTEIEPII TLALPPKESN VIPVLTLGAI DHSLCDSRIR TSEMVSSLEN RYNFNYSSIS
     VGNATFSFTK WKKIAYIHAS SLFITVPKEL MQEIVKNLDA EDLGNCTLAI KSEWNSFATV
     TLGIPFLNQY CAVMEPTAQR ITFLPMKKNF MREFANSP
//