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Database: UniProt
Entry: A0A0N5DRZ5_TRIMR
LinkDB: A0A0N5DRZ5_TRIMR
Original site: A0A0N5DRZ5_TRIMR 
ID   A0A0N5DRZ5_TRIMR        Unreviewed;      5066 AA.
AC   A0A0N5DRZ5;
DT   09-DEC-2015, integrated into UniProtKB/TrEMBL.
DT   09-DEC-2015, sequence version 1.
DT   10-MAY-2017, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:TMUE_s0053000300};
OS   Trichuris muris (Mouse whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichocephalida; Trichuridae; Trichuris.
OX   NCBI_TaxID=70415 {ECO:0000313|Proteomes:UP000046395, ECO:0000313|WBParaSite:TMUE_s0053000300};
RN   [1] {ECO:0000313|Proteomes:UP000046395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|Proteomes:UP000046395};
RA   Hoang H.T., Killian M.L., Madson D.M., Arruda P.H.E., Sun D.,
RA   Schwartz K.J., Yoon K.;
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000046395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|Proteomes:UP000046395};
RA   Foth B.J., Tsai I.J., Reid A.J., Bancroft A.J., Nichol S., Tracey A.,
RA   Holroyd N., Cotton J.A., Stanley E.J., Zarowiecki M., Liu J.Z.,
RA   Huckvale T., Cooper P.J., Grencis R.K., Berriman M.;
RT   "The whipworm genome and dual-species transcriptomics of an intimate
RT   host-pathogen interaction.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|WBParaSite:TMUE_s0053000300}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Edinburgh {ECO:0000313|WBParaSite:TMUE_s0053000300};
RG   Helminth Genomes Consortium;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|WBParaSite:TMUE_s0053000300}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   WBParaSite; TMUE_s0053000300; TMUE_s0053000300; TMUE_s0053000300.
DR   Proteomes; UP000046395; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000046395};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000046395};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4466   4490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4639   4658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4706   4725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4888   4908       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4969   4990       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      116    170       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      177    221       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    285       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      291    352       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      357    415       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      596    820       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1047   1229       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4197   4232       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4233   4267       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4210   4221       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4245   4256       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5066 AA;  574335 MW;  AE528D4C3B6EAD85 CRC64;
     MDWSTLTNLR LKYRPASIEN SAGEQDDISF LRTGDVVCLT CIAPSKETGT GSAERVALAA
     EGFGNRLCYL ENVSDRNVPP DHATSMFYIH QALSVRALRE MMSCDTPGTA GSSSSHRTLL
     YGHAVQLRHV LSTMYLTCLS TSSATDKLAF DVGLCESDSS ESCWWTIHPA SKQRSEGEKV
     RVGDDIILVS VATERYLHMS YSKGMTVIAA FHQTLWSVTP NSSGSVRNRN LGYVFGNDVL
     RLYHGNDECL TIPETWSDHP QQNIVIYESG KSCSQARSLW RPELLHGKWQ GSLIGWEQVF
     RIRHVTSGRF LAITADSQVS LVHKDKATFE STAFITVPSK DVKRTSFEEK EEEGMGMPAL
     KYGETVTFLQ HLQTGLWVSC QTTAVTKKNV GKVEEKKAVA VEEARMDDCF VLFKAQGEEA
     QSARVIRKSS QILNRFLKGL EGLQFEGRDS YQWKRANLLE TVKLMEDLIE YFVQPTEEDL
     DFETMQNRLR ALRNRQDLFQ EEGVLNMIID TIDQLSSVES TGEFSEVMKE TGSREWEQIS
     TYLYLLVAAM IKGNHSNCTQ FASAQRLDWL FNRLSNPQAA EGILDVLYCI LTESPEALNL
     INETHVKSVI SLLEKVGRDP KVLDVLSALC EGNGVAVRSS QNVICNELVC NKNFLLQTRM
     IDQVSSVMAN TFVSVSDGCA IFKRWYFEAE LEYMDSPSSS YLRPHLRVGW ASSAGYVAYP
     GSGRKWGCNG VGDDMYSFGF DGKVMYAGGV NKTVGSRDLS RGDVIGCYID LGIPEIRFSL
     NGNEMSSRFR DFSVNDCLFY PVMSLSATVS CRLILGEPHG KLRYGPPEGF LCVTEAAVTP
     IKIQPCIFYG DYRKGHFSGP STVISDFALF QPKPVDSREI ILPKHLEEAC DRLAENIHEL
     WSMDKIEKGW KYGERRSESQ RIHPCLTNYE RLPNAERAYN MNLARETLKT ILALSYRVDP
     GKMPSRVKTI RLPQSFLMSN GYKPSPLDTR EINLGESLGN LVEQLARNMH NIWAQSKVQR
     GWTYASVENS SFKTSPHLVS YEYLNPTIRA ANREKAGQIV KSLMVYGYTL EPPAMEIDEA
     TTKQTEVLQM KLRTYRMERR YAVTSGKWYF EFEVRTPGFM SVGWMDVDNP PDADLGKGKL
     SFGYDGYLGK KWHGEIEKFG KKWNVGDVVG CFLDLTDRII CFSLNGELLL DASGAEMAFD
     NVNSTGGLVP AFSLAHGQIC RVNFGQNVDS LKFYTTCGLQ EGYEPFCIRM TRPAPLWISK
     FQPEFEEIAD DDKRFKVLRI AQSGDNPPCL KIQCRPMGLQ ERSSLTLFRL NLPVRCEHRS
     TKGTRASAQA SQSTLRDSSR DDATETSTVD TSRRSKSAVP ERRRVEVSFM NGGEPSTPSE
     RQPEKVDAES TRRGSGFLTK TLSLDEDSAI VQRETLKPTV LRSSASEMNL KDKEHSEAPN
     VKLTESLSSA SSKRSRKPFK VFQSFGQRMR DASISRAKKH SAQKTTSSPN TKSRDLSSDG
     SNHFASNREG VLAVDSSESL DMPKTGPGRR PTLVRVDSEK QKQRWNRYLS RGHEFLAEEM
     NLARQSIVQS LKSSLLPSSL AETYTEYYFG LRIYPGQDLA NIWIGWLTPQ FSYSASSGLT
     SAFTQKVVFR ERDGNATDSA QEFRSCYVVN ALDLLAAVSG GSNVSKISGL LAGCIVNTAT
     GELTFHANGR QTEMCFRVET GTLLYPTVFV VPTGKEVLQF ELGRVEKTLP IASAQFNEVT
     NGMQLQCPPR LRIEMCKSRH WSLVPQRCPR VTSLKLSDTR GWSILCDDVA RLMMLYIPER
     DRSLDILELI EYADLQKFHQ HTLQLYCALC AHGNFKIAHI LCRHVDEDQL TYAMKSKYLT
     GQLRQGFCDL LVAMHLSCHY SARLQSNKEY IIPLTEKLKC RNYFSVDCRG MYPHAVNSTV
     SMKPAMDVMP VSEDIYPKDE MFLRSPGFDF DALKRFVIDS LEEATVQALM HSRDLVGGTN
     TSQFAPLLKL FDTLLLVGLF TDEDIQRLFR ILNPSVFDDQ ENSNLVQNNG LLSLELDEEV
     QRHVCYVLSH LCDLLLQGRV ETMISFAESF VGETQNDQLQ RYLYIKQTDM PPAEAARRTK
     EFRCPPKEQM LKLLNFKSND CSMMDEEGEL EVSSMSEYLQ NVLRSFHEGM KRCIGNKPIN
     EEVPLSVEDI YVGEKPVDWV EKLALLVVPV PPDNGNGNAN LIPDGEEAFR RLIISTLTDW
     TSKKHIDDPV LIREIFSLLL RQYTRIDELM KALRTTYCIH ERSIGDVQRF INHLSQIRRL
     LSVQFEAVDE AVLKDCLWEM MNNKVFFQHP DLMRLLKVHE NVMTIMVNVL SRAQQGDEAN
     RRTKDEADAN GNDFKNSISD LVVACCKFLC FICRSSTANQ AAMFEHLPFL LDNATMLLAK
     PSLRGSVPLD VAYYSFMDNS ELSLALKEDE LEKVAFYLSR CGLQANASLV AKGYPDIGWD
     PVEGERYVDF LRFCVWVNGE CVEENANLVI RLLIRRPECL GPALKGQGEG LLRAFKDAIS
     LSSEIHNFNS GKNVRNRFLF DITNYPNPTD EGEDYIDMGA AILGFYSSLV DLLGKCAPDP
     LTINSGKSES LRLRSILRSL TSVDDLEGIL ALRFLLPNVF ASDEESLKAP CYGLLPLHKN
     STLLFLERVY GLVDREMMFR LLEQSFIHDF RAATILDHPS VAESDLALAL NRYLCGTVLP
     LLTNHAHFFA EADHYNSLMD ATLHTTYRMS KIRSLTNNQR AAVTDFLLAL TREISPSMMS
     RLQQKVVRDI SSLNEYAIVP LQIMTQHYEH FSRHYGSSTI EDVANEEQKR LSMLLFTTIF
     DSMGKSAFDQ ELFGRALPCL AAIASALSPD YAASSPEGDE LHKTPTEENE RETLWKPEPV
     DVSHVQLSAG MQNLVLRFAQ HFHDSWASRK LEKGWKYGEA YSRVNLTHPR LRPFGMLKEF
     EQNFYKERCA ECMRAMLAMG YTIEEENPVP ATKAATQQVT PRGSVIFSPQ PVDLSNMSLS
     EEMSDLSERV AQNSHLLWVS KAIEDLSTSS SAIIVQLVPW DILTDSERRK HRFRSQEILK
     FLQYSGCRIK SPVATGGLQG QQSLMSQSGH RSAETRFACN LMVKMLSYIE RAASKMEVVK
     ASKRLSRGSN STLASEDVKF FSKVLLPLLE SYFRSHRNYF IATGSGVGIA SMMEKEIVVS
     LFHRLMSVLR RKLVAFGCNI RTTVRCLQVL ISAIDFKSLV KTNSDSLRTC SQVLFTFVVG
     DLTNIVKSIV KQGRYAEIRG KTLPCTSSLV YLNEVILPVL STLFNHLAQQ GHGPDFLVND
     IQLSSYKIAD SLYALSSAES PSRKSIKLEL ERHRSFIGQC LSAFACCFPV AFLEPEFNEI
     NRFSILARLD QSSQSKELLS SITADIPSLD KVLTDIEHLS QSGGQYQDAP AIFDVHMPTL
     CSYFSSWWQH GPNGNPTDKP ITNVSSDLVN RLFFACAKLI CDHIGVQNAN WVCHVAPFIL
     PMISYVTAEP VKECLLPMTE KIKDKASEAF KEEERQRTHP EVVDEAVVIE LHSVLVRDIY
     AVFPLIIKFT DLHRARWLKN PTLETNNLYE NVAFIFKIWS VSQNMKREEL NFITQLGADT
     FVGGSDLKTG KAAIAIRKKK RREGKKREKD TNSVVVACLK RLLPVGLNVF GGRELELLQK
     IKEKHLKREP EERIKEFIRS SLSVPDKEDI FDKSYWQRQL YHKIGKAQML GISSMNQEAV
     TEAITSMGLT LYNLHTVEHP QTDLAGAWRK ILSSQRKRAV VACFRMVALH SIPRHRCINI
     FLPAYAEKWM EDENMDRDLL ICDLADVRDK GANVKRTKED VEEEDVQLPD SLSQLIQCFQ
     RAATAERKQL VAIEDDELYK EYARVMAISI HIGEEEEDSN ADEAVSMEAQ ELEKQELLHQ
     QARLADRGAA VMVLMYLSAC HGEPNEMVNE TLKLGIHILN GGNSMVQDVM LKYLQDKKDV
     SFFSSIAGLM NRGSVLNLEI FERQIKAEGL GMGAELFLGE HQNLNDAEFI CTLFRFIQLT
     CEGHNSEYQN YLRNQPGNTT SINLIICTVD YLLRLQESIM DFYWHYFSKE LVDEAGKANF
     LRALSVCSQV FNTLTESVQG PCVGNQMALA NSRLWDAING FFFLFANMMD KLSKNHTQLE
     LLREFLSLQK DMIVLMLSML EGNVLNGSIG KQMVDTLAES QQNVQLILKF FDMFLKLKDL
     TTSQAFQEFD LNKDGWISPK EFQRAMEGQK MYSIEEINYL MMCTDVNNDG KIDYMEFTER
     FHNPAKDIGF NLAVLLTNLK EHIVGDNRLD AISQTASSMC DYFDPFLGRI EIMGSNKRVE
     KVYFEIKEEW LEQFNKPQIK QSKKDFLFNV LQDDGGQQGK LEAFVNFCED TIFEMSHAAE
     ISSEDRDSRI ERAKKQREIF TGQSERHDTS ISAYDIVTLG FEKLFLFIQL CYTFCRPSQL
     VKAKTQLRNS LASMTYGELF LSACRFSFRL VCMVAWITYL IVSTLFRFVY FMMGGSKEED
     YVALKSLPEP PRALSRQRSF VSLLPDIEKS DVHKYEAFGV QLSQGTTEAD IAHDHEASKA
     SFSFYIGGSF PEVSKPGFPA DGERPFSGDV PQSSESQRLF EEEDKSRFQG PSVYEPKIAD
     VAPKSRGSLF NVLARNFYAL KYITLALAFL INAILLFYRV SVNTAEISDS FVVQAGAENA
     TTPELEVDEE LSIHENFYYL THLLKFLSIS HCLVSLALLI AYYQLKVPLI IFKREKQVAR
     KLEFEGMWIT EMPSEDAVSG KWDSMVISSA TFPEKYWDKF VKRKVVEKYQ DQFDIEELHR
     LLGLDKQALE NAGNSGSRSV DWRYQLWKVG VIFADGYFQY LMMYLFFSAV GIWNPFFYAG
     HLIDVVISFP MLQTILKSVT HNGRQLILTV MMVVVVVYMY TVLAFNFFRK FYVQDEDGQE
     TDSKCNNMIT CFVFNIYAGI RAGGGIGDEL QSPYGDEKEA WRILFDMTFH FFIIIILLAI
     MQGLIIDAFG DLRDQQESAQ DKLESNCFIC DIGKDFFERL PRGFEHHTAK EHNLAYYLFF
     LMHLINKDET EYTGQESYVW EFTRIS
//
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