ID A0A0N7J8W8_9BURK Unreviewed; 886 AA.
AC A0A0N7J8W8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:ALK89352.1};
GN ORFNames=L63ED372_02149 {ECO:0000313|EMBL:ALK89352.1};
OS Limnohabitans sp. 63ED37-2.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Limnohabitans.
OX NCBI_TaxID=1678128 {ECO:0000313|EMBL:ALK89352.1, ECO:0000313|Proteomes:UP000059510};
RN [1] {ECO:0000313|EMBL:ALK89352.1, ECO:0000313|Proteomes:UP000059510}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=63ED37-2 {ECO:0000313|EMBL:ALK89352.1,
RC ECO:0000313|Proteomes:UP000059510};
RA Ahn J.-H., Kim S.B.;
RT "Limnohabitans sp. 2 strains.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP011774; ALK89352.1; -; Genomic_DNA.
DR RefSeq; WP_062407956.1; NZ_CP011774.1.
DR AlphaFoldDB; A0A0N7J8W8; -.
DR STRING; 1678128.L63ED372_02149; -.
DR KEGG; lih:L63ED372_02149; -.
DR PATRIC; fig|1678128.3.peg.2138; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000059510; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000059510}.
FT DOMAIN 719..735
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 645..652
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 886 AA; 96072 MW; F156D62A799E7B4C CRC64;
MPNDTSPASS PADYAGHTPM MAQYLGIKAE FPDTLVFYRM GDFYELFFGD AEKAAGLLDI
TLTRRGQSAG QPVLMAGVPF HSVETYLARL IKLGESVAIC EQVGDVATAK GPVERKVVRV
VTPGTLTDTE LLSDKSEAIL LAVHQAGKNR CGLAWLSVTQ GVVHLAECGQ DELADWVDRI
SPSELLASAG MTPNFEQKLR GLKTAGRGNW SLALRPDFQF DAGLGQRKLL EQLQAATLAA
WSADTLSDAH AAAAALLTYA EHTQGRSLPH VQRVQVQRSD ALIDLPASTR RNLELTQTLR
GESSADSPTL FALLDTCMTG MGSRLLKSWL LSPPRDRQVA QQRLQAQALL RGDSGSGAWS
SLREQLKGAS DVERITARTA LRQVRPRELV ALRHALARAA SLSTQLKALN PEPGTLLGGM
VRWLTPPTHC AELLQMALLE EPAALVRDGG VIADGLDAKL DELRNIQTHC DDFLLDLETR
EKERTGIANL RVQFNKVHGF YIEVTQGQLD KVPDDYRRRQ TLKNAERFIT PELKTFEDKA
LSAQERALAR EKWLYEGLLD QLQPFVPALT ELAQAMASLD VLCALTERSL TLNWCAPEFT
KEPCIEIRQG RHPVVEARLA QMSGASFIAN DTVLGPKQRL QIITGPNMGG KSTYMRQVAL
IVLLASIGSH VPASRCRMGP IDAIHTRIGA ADDLANAQST FMLEMTEAAQ ILHSATPHSL
VLMDEIGRGT STFDGLALAS GIATHLHNKT QAFALFATHY FELTEFPASH TAAVNMHVSA
AESGASIVFL HELQPGPASK SYGVQVARLA GMPAAVLNHA RHALSALEAG ATESRQQVDL
FAAPPESEAT GPSPIEVALA QINPDALSPR EALDALYALQ RLLPKN
//
