ID A0A0N7M186_9RHOB Unreviewed; 435 AA.
AC A0A0N7M186;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dinB_2 {ECO:0000313|EMBL:CUH82569.1};
GN ORFNames=TRN7648_04111 {ECO:0000313|EMBL:CUH82569.1};
OS Tropicibacter naphthalenivorans.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Tropicibacter.
OX NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH82569.1, ECO:0000313|Proteomes:UP000054935};
RN [1] {ECO:0000313|EMBL:CUH82569.1, ECO:0000313|Proteomes:UP000054935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH82569.1,
RC ECO:0000313|Proteomes:UP000054935};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CYSE01000016; CUH82569.1; -; Genomic_DNA.
DR RefSeq; WP_058249495.1; NZ_FWXX01000019.1.
DR AlphaFoldDB; A0A0N7M186; -.
DR STRING; 441103.TRN7648_04111; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000054935; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR CDD; cd00424; PolY; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:CUH82569.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054935};
KW Transferase {ECO:0000313|EMBL:CUH82569.1}.
FT DOMAIN 8..189
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 435 AA; 47713 MW; 53A1CA4ED989F42B CRC64;
MTAPQVERLY LDFDSFFASA EQHFNPDLRG QPLGVVPLDS PHTSCIAVSR EAKARGVKSG
ASIREARAIL PDMVFVIARH DAYVRLHKRI LDVVGSILPV AKVRSIDEVV CHLTPAEAAQ
GKALSDRIKT ALRDAFSPAL TCSIGMAPTE MLAKVGAEMN KPDGFSLIEA RDLPGCLSHL
DLRDLPGISK GIGARLAAAG VRDIAGLWRL APKQARKLWG NVEGERFWNE LHGFHAERPE
TKKSMYGHGR VLPRDGRAPE QVEACARQLL LSAARRLRRD DLRATQLTLG FRSGRGPDEV
QWSWHDSFAA ARDDRTFTRA LSKGLAEARR SLRFSPRAVH VTLHGLASDD EITGDLFSGA
LDEGADDAIR EKWEKVSDLM DSLRASHGAK ALSLGVRAEI QGGYVGAKIA FGRIPDESDF
SEAPTRDEDT RFLSY
//
