ID   A0A0P0CF87_9FLAO        Unreviewed;      2045 AA.
AC   A0A0P0CF87;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:ALJ04795.1};
GN   ORFNames=APS56_06520 {ECO:0000313|EMBL:ALJ04795.1};
OS   Pseudalgibacter alginicilyticus.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Pseudalgibacter.
OX   NCBI_TaxID=1736674 {ECO:0000313|EMBL:ALJ04795.1, ECO:0000313|Proteomes:UP000057981};
RN   [1] {ECO:0000313|EMBL:ALJ04795.1, ECO:0000313|Proteomes:UP000057981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HZ-22 {ECO:0000313|Proteomes:UP000057981};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; CP012898; ALJ04795.1; -; Genomic_DNA.
DR   RefSeq; WP_054726250.1; NZ_CP012898.1.
DR   STRING; 1736674.APS56_06520; -.
DR   KEGG; ahz:APS56_06520; -.
DR   PATRIC; fig|1736674.3.peg.1331; -.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000057981; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000057981};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..2045
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5006042551"
FT   DOMAIN          969..1109
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1250..1340
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   2045 AA;  236299 MW;  880F3D2A794D26EC CRC64;
     MKHLSAILMT IFFSNLLNAQ PSENYKVLWD KVAQYEKDGL PKSALKIVES IQNQAQKDKN
     HPQEIKTMLY KGKFALVLED DAQLNIINDF KKQIAISSFP TKNILESLLA NLYWQYFNQN
     RWQFYNRTKT SEKVDANDFR TWDLQTLFNE IHFHYQNSLQ NGLMLQQENL EKYNVLLNEK
     DGSKIYRPTL FDFLNHTALE FYKTNETQIT KPAFKFEINN PDFLTDAKSY SVLKISSKDT
     TSLQLNALHI YKNLIKFHLK SPSPFALEDV NIERLKFVNQ HATFPNKETL LLEVLKAESN
     RLKNHKASAL YHFEIASIYF QQSQQYNQTN TKHRWKAKEA MAICKSVISE FPKSKGAEKC
     QVLKSQIEQE SLQIITEEFI PIQQNSRLLV NYKNLENLQF HIYKLSTNQL EKFNKTYRKE
     EQLSFIKTLN VTDTWNSNLR NEEDYQTHST EILIPKLNNG RYLIVASLKN DDTTFAFANI
     QITNMALVEM ETPDYKIFQI VDRNNGDPIT NTTIELSYIQ NYNQNIKTEN YNTNNLGQIK
     IKKSNDRYRN INLKIINEND IAYFGDYYIN QKYNQKQENI NYTSFLFTDR SIYRPGQTVY
     FKGIAIKTEE GKSKTLANQN VYIALYNVND EEIKKIKLKT NEFGSISGEF ILPNNGLNGK
     YRIEFDADSG NIDMKSMTYF SVEEYKRPKF ETKFPPITET FKINDSISVK GMAIAYAGNN
     ITDAKVVYRV HRKVQYPHWY FWYRPWFNSE PQEITHGETI TNNKGEFEIT FKALPDTSID
     KNNLPVFNYE ITADITDLNG ETRSATTIVN VGYHALIANM SIENTIDKTK KNHTINIDTR
     NLNGQFVSAK GVVKIYKLKA PNTVLRPRPW NAPDYQNFNE KAFKNLFPHD AYNNEDNPDN
     WKKGTLVFEE TFDTKTSNTL KLGNIKKWES GKYLITLESK DKFEQLVKDE IKITLFSDND
     KTIADKQLFS ITTNKSTYNI GDTAYVTLVS AVENLNVTVS VEKNKQIIQT EIIHLNTNKK
     TISIPVTKDD LGGFVVHYSF ATFNSFQSGS QPIPVPYPNT NLEIETLTFR DKLQPGNNET
     WSFKIKGPSG EKISTELLAS MYDASLDQFK SHSWNFNPIQ NLSYYAQSHS NANQSFGTRN
     FSVNINRTPP NYPQQVYDQL NWFGFYFGYK NMLYLRKSKG RTANIQITEN ELIEEVSFIK
     VENDAHLDNA LVTNNNQPKA ETETTTVNTN DINEVKNLDS IPIRKNLQET AFFFPQLKTD
     ELGNVSFSFT SPEALTQWKL QLLAHSKTLE SATKTLTTVT QKELMVTPNA PRFLREGDKI
     SIRTKISNLT NKQLSGKAYL ILTDAISGKD ISNTLFNIEG SQNKYFDNSA SNSLGTQDFL
     IDKNGNTQIS WRLSIPDDVP AIQYKIIAKS GDYSDGEQNA LPVLSNRMLV TETLPMWIKS
     NETKTFTLNK LISTRLDPTQ STLSYHKLTL EMTSNPAWYA VQALPYLMEY PYECNEQTFS
     RYYANALASH ITNSNPRIQD VFKQWRNTDA LLSNLEKNEE LKSILIQETP WLRDAQNETE
     QKKRIALLFD LNKMNNELQL ALQKLENNQM YSGGWAWFNG GRENRYITQH IVTGFGHLNK
     LNVTSTMLSN QNKMIQKALN YLDAEFVQEY KDIRKYNANV DLNKDHLSYR QLHYLYMRSF
     FPEIKKSTEV ETIIEYYQTQ IEKYWLSRSL YSKGLMALIS HRNGAVVTAS KILKSLKETS
     ITSEELGMYW KANTNSWFWY QAPIETQALL IETFSEAGTT IQSTSKNLET IDNLKIWLLK
     NKQTNRWKTT KATTDAVYAL LLQGSDWLSL TDMVEVVLGG QKIEPSKLEN VKIEAGTGYY
     KTSWNPSEIK PEMGEVKITK KSNGIAWGSL YWQYFEDLDK ITSAETPLTI KKKLFLKKHT
     DMGEEISEIT ESTNLKVGDL VRVRIELHSD RNMEFLHMKD MRASGFEPIN VISSYKWQDG
     LGYYESTKDA STNFFFDYLP KGVYVFEYDL RANNAGNMSN GITTIQSMYA PEFSSHSEGV
     RININ
//