ID   A0A0P0CJC4_9FLAO        Unreviewed;       271 AA.
AC   A0A0P0CJC4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE            EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN   ORFNames=APS56_04510 {ECO:0000313|EMBL:ALJ04445.1};
OS   Pseudalgibacter alginicilyticus.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Pseudalgibacter.
OX   NCBI_TaxID=1736674 {ECO:0000313|EMBL:ALJ04445.1, ECO:0000313|Proteomes:UP000057981};
RN   [1] {ECO:0000313|EMBL:ALJ04445.1, ECO:0000313|Proteomes:UP000057981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HZ-22 {ECO:0000313|Proteomes:UP000057981};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00001419};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008847}.
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DR   EMBL; CP012898; ALJ04445.1; -; Genomic_DNA.
DR   RefSeq; WP_054725210.1; NZ_CP012898.1.
DR   AlphaFoldDB; A0A0P0CJC4; -.
DR   STRING; 1736674.APS56_04510; -.
DR   KEGG; ahz:APS56_04510; -.
DR   PATRIC; fig|1736674.3.peg.927; -.
DR   OrthoDB; 9808470at2; -.
DR   UniPathway; UPA00070; UER00120.
DR   Proteomes; UP000057981; Chromosome.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04725; OMP_decarboxylase_like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011995; OMPdecase_type-2.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   NCBIfam; TIGR02127; pyrF_sub2; 1.
DR   PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000057981}.
FT   DOMAIN          16..254
FT                   /note="Orotidine 5'-phosphate decarboxylase"
FT                   /evidence="ECO:0000259|SMART:SM00934"
SQ   SEQUENCE   271 AA;  30423 MW;  EBBD10812F5A9940 CRC64;
     MTTSQLIQQI KQKKSFLCIG LDVDLNKLPK HLLKEEDPIF AFNKAIIDAT HHLCVAYKPN
     TAFYEAYGLH GWKSLEKTIN YINEKHPEIF TIADAKRGDI GNTSTMYAKA FFENMAFDSV
     TVAPYMGKDS VEPFLAFENK HTILLALTSN QGAFDFQTKV VDESELYKQV LETSKTWKNS
     ENLMYVVGAT KAEYFADIRK IIPDSFLLVP GIGAQGGNLQ EVCKYGMNHS VGLLINSSRG
     IIYASKTEDF AEIAAIKAKE LQQEMQVLLK T
//