ID A0A0P0NVH3_9CAUL Unreviewed; 1158 AA.
AC A0A0P0NVH3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=AQ619_00555 {ECO:0000313|EMBL:ALL11983.1};
OS Caulobacter henricii.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=69395 {ECO:0000313|EMBL:ALL11983.1, ECO:0000313|Proteomes:UP000056905};
RN [1] {ECO:0000313|EMBL:ALL11983.1, ECO:0000313|Proteomes:UP000056905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB4 {ECO:0000313|EMBL:ALL11983.1,
RC ECO:0000313|Proteomes:UP000056905};
RA Scott D., Ely B.;
RT "Conservation of the essential genome among Caulobacter and Brevundimonas
RT species.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP013002; ALL11983.1; -; Genomic_DNA.
DR RefSeq; WP_062142796.1; NZ_CP013002.1.
DR AlphaFoldDB; A0A0P0NVH3; -.
DR STRING; 69395.AQ619_00555; -.
DR KEGG; chq:AQ619_00555; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000056905; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000056905}.
FT DOMAIN 1..490
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 515..804
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 911..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1158 AA; 125023 MW; 61E18C4D0C653F33 CRC64;
MTGLPDPQRI AADPAISAFV TANAGSGKTK TLIDRVARLL LAGSTPEAIL CVTYTKAAAA
EMQRRLFERL GGWSVTADGP LRAELSKLVG EPEATFDAGA LSRARALFAR ALETPGGLKI
QTIHAFCEKL LRRFPLEAGV SPGFVVMDDS AGAAVARAAR RTVATYVDTH DDAFAEAYAR
FSVALDFAAF ESMFGTFEIR RGDIIGYFAK HGGADGAIGN VWKVCGFDGP TAPESVADEA
MADLDLVVWR EVAEVLISSG GKTDTKCGDQ LAGVARDPDA TLELALGALF TEGGSGTPAT
WPAKTSGLKA RSDLREALLF EQEKLGIARE RVRAARVAQD TAYALLLASR YILDHRAEKA
SRGALDFVDL IEAAKVLLTE KVDAAWVLYK LDGGVDHILL DEAQDTAPDQ WAILRALTAD
FFAGAGAGGW RRSRDVRTLF VVGDEKQSIY SFQGADPQRL LSETQTYIAR IEAVGQVGMG
VPLTMSYRST REVLSFVDAL FSDPATREGV PPPAGDDVVT HQPFRTDGPG CVDLWPLTRE
RPGEERDAWE APLDAEAEHS ANRRLAEAMA AEIKGILDRG DEVHDKETGK RRAAHAGDIL
ILVRRRKVLF EEIIRALKRR NVPVAGADRL SLSAHIAFDD LLALGRFVLF PEDDLTLAAL
LKSPFCGLAD EDVYALARGR KATLWSVLSA RADENPRWTA ARDLLAWALV EGRRRQPFEF
FATLLGKVDA AGLSNRAKVL TRLGGEADEA LDEFLAQVMA AEQRNIRDLE ALVADFAALD
IIVKREMEGA RREVRVMTAH GSKGLEAPIV FLPETTVKRG AGGSPLLATA EGGVLWSTGK
SADCAASTSA RDLRDKKEAE EALRLYYVAL TRARDRLILC GRIDARTRDE NVGGWYAAAR
AAFAHPDIAP EVREIGDPDS PTLRYGPDPR TQPREALAEA MKMPLPGWAQ GLATPEPATA
RYAAPSRIED EADSRAPAPS PLAKVEGLGR YRRGEIIHRL LQILPDVAPA ERRAAGQRLL
AAERDLADDQ RAEMAAAAFG VLEDERFAAV FGPGSRAEVA LAGTSARLPK GLAISGRVDR
LVVTDTRVLV VDYKTNRPAP ASIEQADPAY LAQMAVYVAV LGEVFPDRPV EAALVWTDGP
KLMPVPEKVI ADALRRIG
//
