ID A0A0P0NXY9_9CAUL Unreviewed; 507 AA.
AC A0A0P0NXY9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ALL12940.1};
GN ORFNames=AQ619_06000 {ECO:0000313|EMBL:ALL12940.1};
OS Caulobacter henricii.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=69395 {ECO:0000313|EMBL:ALL12940.1, ECO:0000313|Proteomes:UP000056905};
RN [1] {ECO:0000313|EMBL:ALL12940.1, ECO:0000313|Proteomes:UP000056905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB4 {ECO:0000313|EMBL:ALL12940.1,
RC ECO:0000313|Proteomes:UP000056905};
RA Scott D., Ely B.;
RT "Conservation of the essential genome among Caulobacter and Brevundimonas
RT species.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP013002; ALL12940.1; -; Genomic_DNA.
DR RefSeq; WP_062145453.1; NZ_CP013002.1.
DR AlphaFoldDB; A0A0P0NXY9; -.
DR STRING; 69395.AQ619_06000; -.
DR KEGG; chq:AQ619_06000; -.
DR OrthoDB; 5695497at2; -.
DR Proteomes; UP000056905; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000056905}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 334
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 343
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 347
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 507 AA; 56236 MW; 9493B76185922938 CRC64;
MTDGGLKSLT IVGGGTAGWM SAAMLSRALG STVAITVVES DEIGTVGVGE ATIPAIKLLN
GFLGLDENDF LAATHGTIKL GIEFVDWHTV GQSYLHAFGP VGRPLGMAAF HHYWNRRRLQ
GHDESLWDYS LNARAARAGK FDRLQQAGGG YLEGLVHAFH FDAALYAKYL RRYSEAQGVR
RVEGRIVGVN QHSETGFVTD LTLQDGRRVE GEFFIDCSGF RGLLIEETLK TGYDDWRGWL
PMDSAIAVPC ASATPLLPYT RATAREAGWQ WRIPLQHRTG NGHVFCSEHI SAAEATDVLM
RNLDGAPLAE PRQLNFTTGR RRQFWNKNVV AMGLASGFME PLESTSIHLV QSALSRLVAL
FPNRDFNAVE IAEYNRQTAL EYEYIRDFLI LHYKATSRED TPFWRACKAM DIPDTLKARM
ELFAQSGRVF SQEDDLFKEA SWIQVLIGQG VLPGAVHPLT RQVTDPQLDD YMTNLRQIMA
RAVDGLPDQA DFIARHCASG AQSADRP
//
