ID A0A0P0SID1_9PSEU Unreviewed; 337 AA.
AC A0A0P0SID1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:ALL84099.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:ALL84099.1};
GN ORFNames=AD017_28185 {ECO:0000313|EMBL:ALL84099.1};
OS Pseudonocardia sp. EC080619-01.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=1096856 {ECO:0000313|EMBL:ALL84099.1, ECO:0000313|Proteomes:UP000066228};
RN [1] {ECO:0000313|EMBL:ALL84099.1, ECO:0000313|Proteomes:UP000066228}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC080619-01 {ECO:0000313|EMBL:ALL84099.1,
RC ECO:0000313|Proteomes:UP000066228};
RX PubMed=26535611; DOI=10.1021/jacs.5b09794;
RA Van Arnam E.B., Sit C.S.;
RT "A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.";
RL J. Am. Chem. Soc. 137:14272-14274(2015).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP012184; ALL84099.1; -; Genomic_DNA.
DR RefSeq; WP_060576138.1; NZ_CP012184.1.
DR AlphaFoldDB; A0A0P0SID1; -.
DR STRING; 1096856.AD017_28185; -.
DR KEGG; pecq:AD017_28185; -.
DR PATRIC; fig|1096856.3.peg.5940; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000066228; Chromosome.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ALL84099.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000066228}.
FT DOMAIN 16..189
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..266
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 337 AA; 35320 MW; D47142063F57B3E3 CRC64;
MPEQRPVTRP VTEIRTVACI GAGVIGGGWA AYFLSRGLTV RAWDPAPDAG DKLRRLIDAA
WPALTELGLA EGADPYAIEL FDTAAEAVTG ADFVQESAPE DLALKRSLLA ELAAAAGPGV
IVASSTSGFP MSDMAVDAAD PGALVVGHPF NPPYLIPLVE VVGGEKSEAW ASSAAAEFYR
HIGKSVIEME RELPGFIANR LQEAIWREAL HMVAEGEATP EEIDRSITDG PGLRWPVHGP
CLTFHLAGGE GGMAHMLDHF GPSLKAPWTR LDAPELTTAL RDDMVAGAEV SAGGRPMAEL
VAERDRAVIA VRRAVDTARA AGTAGRAGSP SGEPGRP
//
