UniProt: A0A0P1GHK0

Database: UniProt
Entry: A0A0P1GHK0_9RHOB

LinkDB:  A0A0P1GHK0_9RHOB 
Original site:  A0A0P1GHK0_9RHOB

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (7)   
   InterPro (4)   
   Pfam (3)   
All databases (13)   

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ID   A0A0P1GHK0_9RHOB        Unreviewed;       549 AA.
AC   A0A0P1GHK0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Electron transfer flavoprotein-ubiquinone oxidoreductase {ECO:0000256|RuleBase:RU366068};
DE            Short=ETF-QO {ECO:0000256|RuleBase:RU366068};
DE            EC=1.5.5.1 {ECO:0000256|RuleBase:RU366068};
GN   ORFNames=TRN7648_00263 {ECO:0000313|EMBL:CUH75107.1};
OS   Tropicibacter naphthalenivorans.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Tropicibacter.
OX   NCBI_TaxID=441103 {ECO:0000313|EMBL:CUH75107.1, ECO:0000313|Proteomes:UP000054935};
RN   [1] {ECO:0000313|EMBL:CUH75107.1, ECO:0000313|Proteomes:UP000054935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 7648 {ECO:0000313|EMBL:CUH75107.1,
RC   ECO:0000313|Proteomes:UP000054935};
RG   Swine Surveillance;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accepts electrons from ETF and reduces ubiquinone.
CC       {ECO:0000256|RuleBase:RU366068}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + reduced [electron-transfer flavoprotein] = a
CC         ubiquinol + H(+) + oxidized [electron-transfer flavoprotein];
CC         Xref=Rhea:RHEA:24052, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566,
CC         Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57692,
CC         ChEBI:CHEBI:58307; EC=1.5.5.1;
CC         Evidence={ECO:0000256|RuleBase:RU366068};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|RuleBase:RU366068};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU366068};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU366068};
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DR   EMBL; CYSE01000001; CUH75107.1; -; Genomic_DNA.
DR   RefSeq; WP_058245836.1; NZ_FWXX01000001.1.
DR   AlphaFoldDB; A0A0P1GHK0; -.
DR   STRING; 441103.TRN7648_00263; -.
DR   OrthoDB; 9766632at2; -.
DR   Proteomes; UP000054935; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004174; F:electron-transferring-flavoprotein dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.20; -; 1.
DR   Gene3D; 3.30.9.90; -; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR040156; ETF-QO.
DR   InterPro; IPR049398; ETF-QO/FixC_UQ-bd.
DR   InterPro; IPR007859; ETF-QO/FixX_C.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR10617; ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR10617:SF107; ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL; 1.
DR   Pfam; PF05187; ETF_QO; 1.
DR   Pfam; PF21162; ETFQO_UQ-bd; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|RuleBase:RU366068};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU366068};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU366068};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU366068};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU366068};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU366068};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU366068};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054935};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366068};
KW   Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU366068}.
FT   DOMAIN          210..303
FT                   /note="ETF-QO/FixC ubiquinone-binding"
FT                   /evidence="ECO:0000259|Pfam:PF21162"
FT   DOMAIN          446..546
FT                   /note="ETF-QO/FixX C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05187"
SQ   SEQUENCE   549 AA;  59902 MW;  20D78CF84FABD845 CRC64;
     MSDVTRESME YDVVIVGGGP AGLSAAIRLK QLDADLQVVL LEKGSEIGAH ILSGAVLDPC
     GLDALIPDWK EKGAPLNTPV KEDNFYMLGE AGQIRIPNWP MPKLMNNHGN YIVSMGNVCR
     WMAEQAEELG VEIFPGMACS ELVYGENGEV RGVVAGEFGK EADGSQGPGY EPGMELLGKY
     VFLSEGVRGS LAKEVMAKYD LSEGKDPQKF GIGMKEIWEI DPAKHKEGTV THTMGWPLGG
     NAGGGSFIYH LENNQVYVGF VVHLNYENPY LFPYMEFQRF KHHPMVAELL EGGKRVAYGA
     RAISEGGYQS MPKMVAPGVA LLGCSVGMVN VPRIKGNHNA MLSGKAAAEA AVDAIKAGRS
     ADELTSYETE VRSGPIGKDL KQVRNVKPMW SKWGMTASLA FGGLDMWTNE LFGLSLFGTL
     SHGKSDAEAT GKAARFEPID YPKPDGKLSF DRLTNVAFSF TNHEESQPSH LQLKDPIEPV
     VYNLRNYAGP AQRYCPAGVY EFVEKDGEQQ FVINFQNCVH CKTCDIKDPS QNIQWTVPQG
     GDGPNYPNM
//

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