ID A0A0P1GUM1_9RHOB Unreviewed; 818 AA.
AC A0A0P1GUM1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=pcrA {ECO:0000313|EMBL:CUH86457.1};
GN ORFNames=PH5382_00366 {ECO:0000313|EMBL:CUH86457.1};
OS Phaeobacter sp. CECT 5382.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Phaeobacter.
OX NCBI_TaxID=1712645 {ECO:0000313|EMBL:CUH86457.1, ECO:0000313|Proteomes:UP000050782};
RN [1] {ECO:0000313|EMBL:CUH86457.1, ECO:0000313|Proteomes:UP000050782}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 5382 {ECO:0000313|EMBL:CUH86457.1,
RC ECO:0000313|Proteomes:UP000050782};
RG Swine Surveillance;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CYSG01000001; CUH86457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P1GUM1; -.
DR STRING; 1712645.PH5382_00366; -.
DR Proteomes; UP000050782; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000050782}.
FT DOMAIN 23..342
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 343..617
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 818 AA; 90796 MW; 26989F9BAA053A98 CRC64;
MDAFEGASLS SRAMAARPTP YLDGLNPAQR AAVECLQGPV LMLAGAGTGK TKALTARIVH
LLNTGSARTN EILAVTFTNK AAREMKERVG VMLGQPAEGM PWLGTFHSVC VKLLRRHAEL
ICGEAAPNSD AVVEEIVNSE NPNPYENSGA SATPRRRNTL HLKSNFTILD TDDQIRLLKQ
LIRASGIDEK RWPPRMLAGI IDDWKNRALT PEKLPASDAG AYNHRGPELY AQYQRRLLEL
NAVDFGDLLL HVVTIFQTHS DILAQYQRWF RYIMVDEYQD TNIAQYMWLR LLAGGHKNIC
CVGDDDQSIY GWRGAEVGNI LRFEKDFPGA HVVRLEQNYR STEHILAAAS GVISGNSGRL
GKELWTAEKG GEKVRLIGHW DGEEEARWIG EEIEATQRGT RGQRPIELND MAILVRASHQ
MRAFEDRFLT IGLPYRVIGG PRFYERLEIR DAMGYFRMVT SADDDLAFER IVNTPKRGLG
DKARQTIQGF ARENGVSLLE GARLAVESGA IKGKGGAALR RLVEDLARWG RMTGDADISH
MELAEIVLDE SGYTGMWQAD KNPDSPGRLE NLKELVKALE NFENLQGFLE HVSLVMDNDK
QDSDQKVSIM TLHAAKGLEF PAVFLPGWED GLFPSQRSMD ESGLKGLEEE RRLAYVGITR
AEEICTITFA GNRRVFGQWQ SQLPSRFVDE LPEEHVEVLT PPGLYGGGYG AAASAAEPVR
STIDAKVAQA DGYNSPGWKR MQARAGQRGM SQPKEARSQV IDLAAVSSFT LGERVFHQKF
GYGIILGIEG DKLEIDFEKA GQKKVVARFV SANEDVPF
//