ID   A0A0P1GZV2_9RHOB        Unreviewed;       617 AA.
AC   A0A0P1GZV2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Precorrin-3B C(17)-methyltransferase {ECO:0000313|EMBL:CUH82862.1};
DE            EC=2.1.1.131 {ECO:0000313|EMBL:CUH82862.1};
GN   Name=cobJ {ECO:0000313|EMBL:CUH82862.1};
GN   ORFNames=TM5383_00044 {ECO:0000313|EMBL:CUH82862.1};
OS   Thalassovita mediterranea.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Thalassovita.
OX   NCBI_TaxID=340021 {ECO:0000313|EMBL:CUH82862.1, ECO:0000313|Proteomes:UP000051681};
RN   [1] {ECO:0000313|EMBL:CUH82862.1, ECO:0000313|Proteomes:UP000051681}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8383 {ECO:0000313|EMBL:CUH82862.1,
RC   ECO:0000313|Proteomes:UP000051681};
RG   Swine Surveillance;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CYSF01000001; CUH82862.1; -; Genomic_DNA.
DR   RefSeq; WP_058317038.1; NZ_FTNX01000004.1.
DR   AlphaFoldDB; A0A0P1GZV2; -.
DR   STRING; 340021.TM5383_00044; -.
DR   OrthoDB; 9772960at2; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000051681; Unassembled WGS sequence.
DR   GO; GO:0030789; F:precorrin-3B C17-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR   Gene3D; 3.40.50.11220; -; 1.
DR   Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR021744; CbiG_N.
DR   InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR   InterPro; IPR002750; CobE/GbiG_C.
DR   InterPro; IPR036518; CobE/GbiG_C_sf.
DR   InterPro; IPR038029; GbiG_N_sf.
DR   NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR   PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR   Pfam; PF01890; CbiG_C; 1.
DR   Pfam; PF11760; CbiG_N; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR   SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   4: Predicted;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:CUH82862.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051681};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CUH82862.1}.
FT   DOMAIN          56..135
FT                   /note="Cobalamin synthesis G N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11760"
FT   DOMAIN          217..336
FT                   /note="CobE/GbiG C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01890"
FT   DOMAIN          352..568
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
SQ   SEQUENCE   617 AA;  63435 MW;  9EC9691CB0A050D1 CRC64;
     MAVTAGNENV KPVVLALSAS GEAVARKVAD LLGAELHGRE GRVAEADAFF PNALDHARDL
     FTAGVPVVGV CASGILIRAV APMLSDKRAE PPVVSVSDDG SVVVPLLGGH RGANRLAGQI
     AEALNATAAV TTAGDVAMGV ALDEPPQGWV LANPDNAKAA MAALLSGAGA SVVGEAAEAA
     DWLSGLPKGD GVTIHATVAP VEVTDETTLV FHPQHAVLGV GCSRNCPAEE LDGLVAELLS
     DAGVASGALA AIATADLKAD EPAMNALAAK FNVPLRLFTA AELDAETPRC ATSSDVVFAE
     IGTHGVAENA ALAAGGAAVT LTEPKRKTAM GTAALAMAVS PVLDIAGRAR GRLSVVGIGP
     GQSAWRTPEV SRLVAEAEEL VGYGLYIDLL GPLAAGKERS DFPLGGEEAR CRYALEQAAK
     GKNVALVCSG DAGIYAMGAL VFELLDRGPD EHGVSDAAHR VEVVCSPGVS ALQGAAARAG
     APLGHDFCTI SLSDLLTPRD DILRRLKAAA EGDFVIAFYN PVSKTRRTLL AEARDILLQH
     RPADTPVMLA SSLGRPEEYV RYRRLDQLEV DEVDMLTVVL IGSSNSRLAE LGEGPRMFTP
     RGYARKIDGD LSGKAAK
//