ID A0A0P1IVH8_9RHOB Unreviewed; 298 AA.
AC A0A0P1IVH8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:CUK10741.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:CUK10741.1};
GN Name=garR_2 {ECO:0000313|EMBL:CUK10741.1};
GN ORFNames=PH7735_03487 {ECO:0000313|EMBL:CUK10741.1};
OS Shimia thalassica.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae.
OX NCBI_TaxID=1715693 {ECO:0000313|EMBL:CUK10741.1, ECO:0000313|Proteomes:UP000051870};
RN [1] {ECO:0000313|Proteomes:UP000051870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 7735 {ECO:0000313|Proteomes:UP000051870};
RA Rodrigo-Torres Lidia, Arahal R.David.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CYTW01000005; CUK10741.1; -; Genomic_DNA.
DR RefSeq; WP_058312659.1; NZ_CYTW01000005.1.
DR AlphaFoldDB; A0A0P1IVH8; -.
DR STRING; 1715693.PH7735_03487; -.
DR GeneID; 83882464; -.
DR Proteomes; UP000051870; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CUK10741.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051870}.
FT DOMAIN 5..165
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 168..288
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 174
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 298 AA; 30578 MW; E835C084EC233E09 CRC64;
MSKPNIGFIG LGLMGAAMVN RLLDQGYSVT LMANRSRPNV DAVVARGATE VSTARDVAAA
SDIVMLCMDT SASVEGRMRG QDGVIAGLQS NAVVIDFGTS LPASTRALGA EVAQAGGDYL
DAPLGRTPAH ALDGLLNIMA AGDKAAFDKV KPVLEDLGEN VFHLGALGAG HTIKLINNFF
GMTVANAMAE AFAMADVAEV DRASLYNVMS AGPLHSGMMD FVKAYGVDGD PSMLAFAIKN
AAKDVGYYSQ MAKDAGVASQ IAPGPLGAMT AAVAEGHGDD MVSQMVDFYA GKFSGTAT
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