ID A0A0P5T7E4_9CRUS Unreviewed; 1834 AA.
AC A0A0P5T7E4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Epidermal growth factor receptor substrate 15 1-like protein {ECO:0000313|EMBL:KZS16292.1};
DE SubName: Full=Intersectin 1 long form variant {ECO:0000313|EMBL:JAL72095.1};
GN ORFNames=APZ42_017917 {ECO:0000313|EMBL:KZS16292.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAL72095.1};
RN [1] {ECO:0000313|EMBL:JAL72095.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAL72095.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KZS16292.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS16292.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS16292.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; GDIP01131619; JAL72095.1; -; Transcribed_RNA.
DR EMBL; LRGB01000725; KZS16292.1; -; Genomic_DNA.
DR STRING; 35525.A0A0P5T7E4; -.
DR EnsemblMetazoa; XM_045175677.1; XP_045031612.1; LOC116934110.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11836; SH3_Intersectin_1; 1.
DR CDD; cd11837; SH3_Intersectin_2; 1.
DR CDD; cd11838; SH3_Intersectin_3; 1.
DR CDD; cd11839; SH3_Intersectin_4; 1.
DR CDD; cd11840; SH3_Intersectin_5; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 3.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Receptor {ECO:0000313|EMBL:KZS16292.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..98
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 42..77
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 306..395
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 339..374
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 766..827
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 910..968
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 985..1043
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1133..1197
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1238..1297
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1343..1528
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1690..1808
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 416..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 668..699
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 436..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1834 AA; 202954 MW; E1BE05167A28B51B CRC64;
MDPFVILPQE KARYVEQFNS LKPAGGFVSG DQAKGFLLQS QLPPVILGHI WELADVNSDG
KLDFTEFSIA CKLINAKLRG FDIPKVLPPN LRNSASSGLT TSSAGTPPAT MMGVPLAPLG
MTPSAVIQPL TMAAAKPPST VMAPHLNNQP LVQPTIQPMI QPMAQPMMQP MMQPMMQPMM
QAVLQPTMQP IMQPTMQTTI QPIIQPMMQP MMQPMIQPIV PVNLPLLGAG SPVGLPLMAN
NMPGNAGIVS PPSAAAASAV VSGFPGSSFS FDGSKPNTPD STKTVARAPS IASRESSIEW
TVPHSSKLKY AQVFNSHDRG KTGFLTGVQA RGILVQTQLP QPLLARVWGL SDIDMDGRLS
CDEFVLAMHL CDTVRAGDKL PDVLPHDLVP PCFRRPSLPT VTGLVVSPKG SSTPDLLAQA
FAGTSPPPSD DVKVTSPVSF EDKRKENFDK GQAELDKRRK ALAEQQRREQ EERQRKEREE
YERKEKLRLE QERRQQAELE KKMAKQRELE MEKEEQRRKM LEQREAARKE MERQRQLEWQ
KQRLQELLQQ RQKEQEKVAL LRANHQRLQT ELSVLDDRVM ELSSKIIETR TGVAETKNTI
DGMRTTRDTQ MQQLSALKTQ LRDQNQRLLS VSQEKVRLEA KNRINAATTP NAVDAELTQN
TTARQIALNQ SKEKLQLLTE ELNKKLEDSE NNNAQLSTLR TEMSILARTC QETHKAYLKK
REEVLLLRAT GGKQQSWSND SWSDSANSWP VSTGATPAAV DVSSNSGLTR YRALYEFVAR
NGDEISFQPG DIIMVTESLS NEPGWLSGEV RGHVGWFPEA YVEKMDQAGW PDTGSSTAGS
NVDSPITGAK RHPLEGIQEL PENVSDNGSI ADAGASVSAA IEASHSAFMP VGTRVSEDSS
SPIRGQGEIV DNLKAEAIYV WQGKKDNHLS FNKGDVILVR EQQDLWWFGQ CNGRSGWFPK
SFVSLFHTDA APLSPKSIVS TQNTKEDNYY VAMYPYESNE PGDLSFVAGE MVTIIKKDGD
WWTGTIGART GVFPSNYVQK AELQYEAAAD SEVEAASAAA DAAAAAAVAA AAAAVAKTVT
PNVKAATSQL DSKRPNTAPI DSEFEASLPG IPRAASAASS GAPSPSNMGR GSKKPEIATV
IAPYSATSSE QLSLQRGQLI MIRKKSASGW WEGELQAKGR KRQLGWFPAS YVKVLSSSGG
SSRTTPVPAE MDDEMPQMPP TVPTQTAITA AFEVNNTPTL DQVVALFPYT AQNEDELSFL
QGDVLIILDR EDPAWWRGEL KGQTGLFPSN YVEVMGSLAA SAALGAAASS ASASVASTAT
SQWATSRQTD AAAFSKLSPT EKKRQIVIQE LISTEETYME DMSIVNEVFQ KPMIESGVVK
LEDVDTIFVN WKDIIACNNT FLRALRIRKK MSPGGVIQAV GDILIDCLPH MSPYIRFCSR
QLNAAALIQR RHEGVPEFRA LLKKCQLHPK VKGMPLTSYL LKPMQRITKY PLLIKKILES
TDVDHPDRLL LDEALVKAEE LCNQVNEGVR EQENSDRLEW LQRRVHIEGL DERLVFNSVT
NMLGPRKLIH FGPLKKVKSS KELLAFVFND FLLFTTINKP LASINLQFLF DKKSSVTLRM
YRKPIFLREM SVVPGDNQPT EGGNEHESVP TRFTIQDTAC KLLVTCTSSA DRILWLRKLE
EARKHCLLTE RAVLQRQRSK QNEGNVCGRL LVLVIEAENL QPSSETGKSD TFCEVYLGSQ
EHRTKVVPKS LNPKWNASMQ FLVKDLQQDV LCITVLDRDY FSPNEFLGRT EVRIADVLQD
SKIYRGPLIK RLPLHEVECG EIVLKLDLQL FKSR
//
