ID A0A0P5WRY4_9CRUS Unreviewed; 1129 AA.
AC A0A0P5WRY4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Regulator of nonsense transcripts {ECO:0000313|EMBL:JAM20637.1, ECO:0000313|EMBL:KZS21548.1};
GN ORFNames=APZ42_011505 {ECO:0000313|EMBL:KZS21548.1};
OS Daphnia magna.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=35525 {ECO:0000313|EMBL:JAM20637.1};
RN [1] {ECO:0000313|EMBL:JAM20637.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D., Podicheti R., Orsini L., Colbourne J., Pfrender M.;
RT "Daphnia magna gene sets from two clonal populations assembled and
RT annotated with EvidentialGene.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAN58640.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RT "EvidentialGene: Evidence-directed Construction of Complete mRNA
RT Transcriptomes without Genomes.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:JAM20637.1}
RP NUCLEOTIDE SEQUENCE.
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KZS21548.1, ECO:0000313|Proteomes:UP000076858}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinb3 {ECO:0000313|EMBL:KZS21548.1,
RC ECO:0000313|Proteomes:UP000076858};
RC TISSUE=Complete organism {ECO:0000313|EMBL:KZS21548.1};
RA Gilbert D.G., Choi J.-H., Mockaitis K., Colbourne J., Pfrender M.;
RT "EvidentialGene: Evidence-directed Construction of Genes on Genomes.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; GDIP01217965; JAJ05437.1; -; Transcribed_RNA.
DR EMBL; GDIP01169215; JAJ54187.1; -; Transcribed_RNA.
DR EMBL; GDIP01120272; JAL83442.1; -; Transcribed_RNA.
DR EMBL; GDIP01101180; JAM02535.1; -; Transcribed_RNA.
DR EMBL; GDIP01083078; JAM20637.1; -; Transcribed_RNA.
DR EMBL; GDIQ01036097; JAN58640.1; -; Transcribed_RNA.
DR EMBL; LRGB01000024; KZS21548.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P5WRY4; -.
DR STRING; 35525.A0A0P5WRY4; -.
DR EnsemblMetazoa; XM_032922230.2; XP_032778121.1; LOC116916925.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000076858; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000076858};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 95..252
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 103..135
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 117..145
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 163..193
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 991..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1129 AA; 125823 MW; ACE6AB11A47FB153 CRC64;
MSVDTFGPNS QTLTFLDTEE NDLLGADTQG TDFDFRDFTL PSQTQASQID HASLHKSMGK
HQANGLESID SQLASAMKNL NDLQFEEEDE EGYYSKDLPP HACKYCGIHD PGCVVMCNIC
KKWFCNGKGN TSGSHIVNHL VRAKHKEVTL HRDGPLGETV LECYSCGVRN VFVLGFIPAK
ADSVVVLLCR QPCAAQSSLK DMNWDIEQWK PLIADRCFLS WLVRSPSEAE QMRARQLTAQ
QLNRLEEMWK EKPEASFEDL ERPGVDEEPQ HVLLRYEDGY QYQNIFGPLV KLEADYDRRV
KEAQTQDNVH VRWDVGLNKK TVAYFSLQKT DSDMKLMHGD ELRLRYLGEL HKPWTGLGHV
IKLPDNYGEE VGIELKNSNG APTECSTNFV VDFVWKSTSF DRMQSALRKF AVDESSVSAY
IYHRLLGHEV EDVVFRLHLP KHFSAPDLPE LNRSQVFAVK QAVQRPLTLI QGPPGTGKTV
TSATIVYHLA KLGSGPVLVC APSNIAVDQL TEKIHRTGLK VVRLCAKSRE AIDSPVSFLA
LHNQVRCLEG ASELRKLVQL KEEVGELSQG DEKRYRMLKR QAERELLEAA DVLACTCVGA
GDVRLARIKF ASILIDESMQ ATEPECMVPV VLGARQLILV GDHCQLGPVV MCKPAAKAGL
SQSLFERLVV LGIRPFRLEV QYRMHPRLSE FPSNFFYEGS LQNGVCAEDR ILRGVDFPWP
MPDRPMFFYV TLGQEEIAGS GTSYLNRTEA SNVEKIATRF LRSGVKPEQI GIITPYEGQR
AYLVQYMQHQ GSLHAKLYQD IEIASVDAFQ GREKDIIIMS CVRSNENQGI GFLNDPRRLN
VAMTRARYGI IIVGNPKVLA KQPVWNHLLH FYKENHVLTE GALNNLKESM MQFPKPKKPI
NSFNPGQHFM STAVYDARQA MVPGSVYDRS GGGQPPNNNG ISTYIPRATA NVGDPYSRLH
DPIGYIAPER AQAALSAMPV PLGVFMNMTH VPPRFHGQQP QGLHSNSKPN QRPKESARAS
GPRAGKVSSK GGSSLFTQSL SQNTQDVSTQ PFSQGGMALT QGMSQGMSQT VSGFGALSQS
GLSQLDPSQD PYLSSDYQSQ MDGLLSQDST YQGGRSAFFR HGSQFTQPY
//
