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Database: UniProt
Entry: A0A0P6Y2E6_9CHLR
LinkDB: A0A0P6Y2E6_9CHLR
Original site: A0A0P6Y2E6_9CHLR 
ID   A0A0P6Y2E6_9CHLR        Unreviewed;       491 AA.
AC   A0A0P6Y2E6;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Probable glycine dehydrogenase (decarboxylating) subunit 2 {ECO:0000256|HAMAP-Rule:MF_00713};
DE            EC=1.4.4.2 {ECO:0000256|HAMAP-Rule:MF_00713};
DE   AltName: Full=Glycine cleavage system P-protein subunit 2 {ECO:0000256|HAMAP-Rule:MF_00713};
DE   AltName: Full=Glycine decarboxylase subunit 2 {ECO:0000256|HAMAP-Rule:MF_00713};
DE   AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) subunit 2 {ECO:0000256|HAMAP-Rule:MF_00713};
GN   Name=gcvPB {ECO:0000256|HAMAP-Rule:MF_00713};
GN   ORFNames=SE15_08250 {ECO:0000313|EMBL:KPL83224.1};
OS   Thermanaerothrix daxensis.
OC   Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC   Thermanaerothrix.
OX   NCBI_TaxID=869279 {ECO:0000313|EMBL:KPL83224.1, ECO:0000313|Proteomes:UP000050544};
RN   [1] {ECO:0000313|EMBL:KPL83224.1, ECO:0000313|Proteomes:UP000050544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GNS-1 {ECO:0000313|EMBL:KPL83224.1,
RC   ECO:0000313|Proteomes:UP000050544};
RA   Hemp J., Ward L.M., Pace L.A., Fischer W.W.;
RT   "Whole genome sequence of Thermanaerothrix daxensis DSM 23592.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine through
CC       its pyridoxal phosphate cofactor; CO(2) is released and the remaining
CC       methylamine moiety is then transferred to the lipoamide cofactor of the
CC       H protein. {ECO:0000256|ARBA:ARBA00003788, ECO:0000256|HAMAP-
CC       Rule:MF_00713}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC         complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC         L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC         Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC         ChEBI:CHEBI:83143; EC=1.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00033655, ECO:0000256|HAMAP-
CC         Rule:MF_00713};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00713};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. In this organism, the P 'protein' is a heterodimer of two
CC       subunits. {ECO:0000256|HAMAP-Rule:MF_00713}.
CC   -!- SIMILARITY: Belongs to the GcvP family. C-terminal subunit subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00713}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPL83224.1}.
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DR   EMBL; LGKO01000004; KPL83224.1; -; Genomic_DNA.
DR   RefSeq; WP_054521635.1; NZ_LGKO01000004.1.
DR   AlphaFoldDB; A0A0P6Y2E6; -.
DR   STRING; 869279.SE15_08250; -.
DR   PATRIC; fig|869279.4.peg.2379; -.
DR   OrthoDB; 9801272at2; -.
DR   Proteomes; UP000050544; Unassembled WGS sequence.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   CDD; cd00613; GDC-P; 1.
DR   Gene3D; 6.20.440.10; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   HAMAP; MF_00713; GcvPB; 1.
DR   InterPro; IPR023012; GcvPB.
DR   InterPro; IPR049316; GDC-P_C.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR   Pfam; PF21478; GcvP2_C; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW   Rule:MF_00713}; Pyridoxal phosphate {ECO:0000256|HAMAP-Rule:MF_00713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050544}.
FT   DOMAIN          351..451
FT                   /note="Glycine dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21478"
FT   MOD_RES         265
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00713"
SQ   SEQUENCE   491 AA;  53698 MW;  2423B19B3987FE12 CRC64;
     MTEPTLFELS SPGRRGVRFP EPDVPKSALP EGFVRKDLPL PELAEVDVVR HFVRLSQKNY
     AVDYGLYPLG SCTMKYNPKI NEDAARLPGF ALAHPLQPID TVQGSLALMY ELQELLKEIT
     GMGAVSLQPA AGAHGELTGV LIIRAYHQSR GDTKRTKILI PDSAHGTNPA SSAMSGYEVV
     QLPSDKRGNV DLEALKAACD ETVAGLMLTN PNTLGLFEEN VLEVTRVVHE AGGLVYGDGA
     NLNALLGIAR PGDMGFDILH LNLHKTFSTP HGGGGPGSGP VAVTETLAEF LPGPIVTILE
     EGSEEVPPLY GFKMPNRSIG RVKAFHGHFG MMVRAYTYIL MHGAEGLRKV AEHAVLNANY
     LLARLRHVYH IPYDRICKHE FVAEGIWDDA PGVHALDIAK RLIDYDFHPP TNYFPLIVRE
     ALMIEPTETE SKQTLDKFAD ALIKIAEEAH TQPELLKSAP HHTPVGRLDE VKAAKELVLC
     CWFPEKESQA A
//
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