ID A0A0P7BA96_9HYPO Unreviewed; 1211 AA.
AC A0A0P7BA96;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ras guanine nucleotide exchange factor A {ECO:0008006|Google:ProtNLM};
GN ORFNames=AK830_g7437 {ECO:0000313|EMBL:KPM39139.1};
OS Neonectria ditissima.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Neonectria.
OX NCBI_TaxID=78410 {ECO:0000313|EMBL:KPM39139.1, ECO:0000313|Proteomes:UP000050424};
RN [1] {ECO:0000313|EMBL:KPM39139.1, ECO:0000313|Proteomes:UP000050424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R09/05 {ECO:0000313|EMBL:KPM39139.1,
RC ECO:0000313|Proteomes:UP000050424};
RA Gomez-Cortecero A., Harrison R.J., Armitage A.D.;
RT "Draft genome of a European isolate of the apple canker pathogen Neonectria
RT ditissima.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM39139.1}.
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DR EMBL; LKCW01000115; KPM39139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7BA96; -.
DR STRING; 78410.A0A0P7BA96; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000050424; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000050424};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 67..133
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 739..859
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 918..1169
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 18..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1211 AA; 133059 MW; 313F4E0123CB9BB6 CRC64;
MLSSQPMRAS LQVAPLTISK LQGDSTGDGS STSDLDTNPY SQSHMTPPAT PNGSQEDLSP
QYLAPPVFHN FLRAFYPFNP SYAMSDSSVT LPLNEGDVIL VHSIHTNGWA DGTLLVSGAR
GWLPTNYCES YDPDDMCSLL KALLNFWDLL RSTTVNDREI FGNQEFMKGI IAGVRFLLER
TNCLNRESPF IQRNDSLRRC RKSLLSELSS LVKSAKRLQE RQRPATIPIE DEVNDIVDEM
ILKAFRIVTK GVRFVDVLEE DRRARAPASV TVMATVLEES YVPPTPPADQ ATFDEQTTRT
TNDTDSQAAA SVATSESSES TQTTMALFNR RLSSLGSPTG PSTHRLSQAS LVQAHRLSAS
ISHRVSLAGP SPLSRAHHLV SERLNRTHDT FLSHLGSFIG RLHLQSQSRP ELASAIKQSA
LSGGELLAVV DGVYEHINSS SQILAQARAI MFERIQDLVF SARDTLVNAE SEEADVIMPQ
DNSILLMSAT GCVRAAGDCV AKAKVAIERI GDFEFEMESS SLGIDLSILD IAPEERSRTP
SVSEPGVALN VDDSHRSSSG SSTLAPRRLT LVGVDKPLPE VPQDATTPTE EQTPQHPSPV
SSRPSSVNDD HLSSMASSIS SLRPSLPPLP KLSTSLLPTD DYSPIDNHDN EFSSTSRFDS
MVASSAGSSA TYLSRDSESS IVSQSSTRAT TPDHSLAPRN QPSMSELSTA GSSSQAEEVD
DVESRLMEKT FAHELMFNKE GLVTGGSLQA LVERLTTHES TPDAMFVSTF YLTFRLFCAP
VRLAEALIER FDYVNESTHM AGPVRLRVYN AFKGWLESHW RDETDREALS LIMPFSEIKL
GSVLPSAGRR LLELAQRVSG EGSLVPRLVS SMGKTNTSIA QYVPADTPLP QPTVSKAQTN
LLATFKNGAS APTILDFDSL ELARQLTIKQ MNIFCSILPE ELLGSQWMKK GGVAAPNVKA
MSSLSTDLSN LVAETILQQV EIKKRAAVIK QWIKIAHQCL ELHNYDGLMA IICSLNSSTI
SRLRKTWDMV SAKRKEMLRN LQALVEPSQN NKVLRTRLHD HVPPCLPFLG MYLTDLTFVD
IGNPATKQMS LGNDSEDDGN NGITVINFDK HTRTAKIIGE LQRFQIPYRL IEVPDMQDWM
SAQIQRVREG DQGNVQVSYY RKSLLLEPRE TALRPPLESQ LSLSAMNASR TDLFAWMSRD
RGAQTPTPAP V
//
