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Database: UniProt
Entry: A0A0P7UIE9_9TELE
LinkDB: A0A0P7UIE9_9TELE
Original site: A0A0P7UIE9_9TELE 
ID   A0A0P7UIE9_9TELE        Unreviewed;      1974 AA.
AC   A0A0P7UIE9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-MAY-2017, entry version 10.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=Z043_106824 {ECO:0000313|EMBL:KPP74045.1};
OS   Scleropages formosus (Asian bonytongue).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX   NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP74045.1, ECO:0000313|Proteomes:UP000034805};
RN   [1] {ECO:0000313|EMBL:KPP74045.1, ECO:0000313|Proteomes:UP000034805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aro1 {ECO:0000313|EMBL:KPP74045.1};
RA   Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT   "The genome of the Asian arowana (Scleropages formosus).";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPP74045.1}.
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DR   EMBL; JARO02001923; KPP74045.1; -; Genomic_DNA.
DR   Proteomes; UP000034805; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034805};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KPP74045.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    114    134       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    179    198       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    210    231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    237    256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    340    367       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    707    725       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    737    760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    772    796       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    817    850       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    907    930       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1221   1240       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1252   1278       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1298   1324       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1419   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1520       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1582       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1619   1647       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1721   1746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      119    374       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      445    656       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      707    934       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      944   1176       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1180   1451       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1501   1756       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      364    409       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1974 AA;  224267 MW;  7CCCF18D3AAFD158 CRC64;
     MTGSKVQDEK MAQLLVPPGP DSFLPFCRES LIAIEKRIAE EKAKRPKAER RDEDDENGPK
     PNSDLEAGKS LPFIYGDIPV GLVSTPLEDL DPYYSTEKTF IVLNRGKAIF RFNATPAFFV
     IMCTILTNCA FMTLSNPPDW AKNVEYTFTG IYTFESLIKI LARGFCVGKF TFLRDPWNWL
     DFSVILMAYV TEFVDLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS VKKLSDVMIL
     TVFCLSVFAL IGLQLFMGNL RHKCVKTWNG TNFNQTQFNW TEYVNDEKGF LCMKAGRNPD
     YGYTSFDTFS WAFLSLFRLM TQDFWENLYQ QTLRAAGKTY MIFFVLVIFL GSFYLVNLIL
     AVVAMAYDEQ NQATMEEAQQ KEEEFQAMLE QLKRQQEEAQ AAAAAAATES GESSGKGGPT
     ETSSEASKLS SKSAKERRNR RKKRRQREEG DDDRADNEKF HKSESEDSIK RTGFRFSIDG
     NRLSYEKRHS SPHQSLLSVR GSLFSPRRNS RASLFSFRGR ARDVGSENDF ADDEHSTLED
     SESRRGSLFV PRRVERRSSN ISQSSVSSRV LLPANGKMHC TVDCNGVVSL VGGASVPTSP
     AGLLLPEVTV DKATTEDNGT TTETEIQKKK RSSSHQTSME FLEDPVARQR ALSVASILTN
     TMEELEESRQ KCPPCWYKFA NIFLIWDCCP LWLKIKEIVS LIVMDPFVDL AITICIVLNT
     LFMAMEHYPM TKDFNNVLSV GNLVFTGIFT AEMVFKIIAL DPYYYFQEGW NIFDGIIVSL
     SLMELGLANV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF
     IFAVVGMQLF GKNYRDCVCK ISEDCTLPRW HMFDFFHSFL IVFRVLCGEW IETMWDCMEV
     SGQTMCLIVF MMVMVIGNLV VLNLFLALLL SSFSADNLAA TDDDSEMNNL QIAVGRIHRG
     IDFVKATLRQ FFQSLCVGKN QRALDEVKAL EELHSKGENC ISNHTAVDFN REPEYLKEGN
     GTASGLGSGM GKYMIDDSDY MSFIHNPSLT VTVPIAVGES DFENLNTEDF SSESSDIEGS
     KESWLPWRMQ ASHVKDLLVT RCNNASLVGL SLQKLADPQL SSSEGSTVDI RPPGEGGESV
     EMEPEESMDP EACFTEVSLE DTKWKIWWTL RKTCYRIVEH NWFETFIIFM ILLSSGALAF
     EDIYIEQRKT IKTMLEYADK VFTYIFILEM LLKWVAYGFV KYFTNAWCWL DFLIVDVSLV
     SLVANALGYS ELTAIKSLRT LRALRPLRAL SRFEGMRVVV NALLGAIPSI MNVLLVCLIF
     WLIFSIMGVN LFAGKFYHCV NTTTDDMFSI DIVNNMTQCL ALGDRARWKN VKINFDNVGA
     GYLALLQVAT FKGWMDIMYA AVDSRDVEDQ PVYEENLYMY LYFVIFIIFG SFFTLNLFIG
     VIIDNFNQQK KKIRGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPANKF QGCVFDIITK
     QAFDIVIMIL ICLNMVTMMV ETDDQTKEMD NILYWINLVF IVLFTGECVL KMISLRHYYF
     TVGWNVFDFV VVILSIVGMF LSELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL
     FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKKEAG IDDMFNFETF GNSMICLFQI
     TTSAGWDGLL APILNKREPD CDSEVEHPGS SYKGNCGNPS VAIFFFVSYI IICFLIVVNM
     YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPDAT QFVEYDKLSS FADALDPPLR
     IPKPNKIQLI AMDLPMVSGD RIHCLDILFA FTKRVLGEGG EMDALRGQME ERFMASNPSK
     VSYEPITTTL RRKQEEMSAI VIQRAFRRYL IKRTVKKASK MYKENISDGG KLLDKEVLVI
     DKLNENSTSD KTDVTPSTAS PPSYNSVTKP DKNKYEKDKR EKEDKDKDNR ENRK
//
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