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Database: UniProt
Entry: A0A0P7UQ08_9TELE
LinkDB: A0A0P7UQ08_9TELE
Original site: A0A0P7UQ08_9TELE 
ID   A0A0P7UQ08_9TELE        Unreviewed;      2145 AA.
AC   A0A0P7UQ08;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-MAY-2017, entry version 10.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=Z043_109874 {ECO:0000313|EMBL:KPP71232.1};
OS   Scleropages formosus (Asian bonytongue).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX   NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP71232.1, ECO:0000313|Proteomes:UP000034805};
RN   [1] {ECO:0000313|EMBL:KPP71232.1, ECO:0000313|Proteomes:UP000034805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aro1 {ECO:0000313|EMBL:KPP71232.1};
RA   Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT   "The genome of the Asian arowana (Scleropages formosus).";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPP71232.1}.
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DR   EMBL; JARO02003077; KPP71232.1; -; Genomic_DNA.
DR   Proteomes; UP000034805; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034805};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KPP71232.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     12     31       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    411    433       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    445    472       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    478    497       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    509    530       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    536    556       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    633    652       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    672    699       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    846    870       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    904       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    916    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    961    990       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1045   1075       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1300   1319       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1340   1362       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1368   1388       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1417   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1541   1564       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1651   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1681   1699       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1711   1731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1768   1796       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1872   1895       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      415    706       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      853   1079       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1089   1294       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1300   1572       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1650   1905       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      696    737       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KPP71232.1}.
SQ   SEQUENCE   2145 AA;  241467 MW;  5D75F77791F74B10 CRC64;
     RSGDRRKVGP CHFVIIATII ITIMIIIIII ATTTSTAPMR TVGAAVVEQR GLQWRSDALV
     PPGAVGRWCH RTYTSRPEGA LEHTWPLPPY PPDPRPSAAN PCKPEPGGHG IPPQALVRHE
     DQVAALNRLG SSPSLAPGLR FGSRLSRRQR DVLRAAVTCE VSFPENSSDR RLEKVVVTLE
     RTSRVHVTRH LPFALSLKCG RCAGALGRAP LFSWTLRGPS GTRTPSRVDS VAIPACSGPA
     HLAGGASSGL PRLRASWRHM RLERKADAHC REPGVVVSLR DAKMASQLPK NSAAIAKLRR
     FSPESLAQIE ERIQAKEKAK DEGLEEEPLA PSNDLEAGKD LPMIYGELPA ELFNEPLEDL
     DPFYSTQKTF IVISKGNTIY RFNAEPACYI LSPFNIVRRG AIRILIHSYP FFHIFTNMFI
     MITILSNCVF MTMSNPPAWS KTVEYVFTGI YTFEATVKVL SRGFIIGSFT FLKDPWNWLD
     FMVISMAYIT EFVDLGNVSA LRTFRVLRAL KTITVIPGLK TIVGALIQSV KKMVDVMILT
     VFALAVFALV GLQLFMGNLR HKCVLWPPPN NGTWTSGNST DNSTLDFDEY IGSEENHYYL
     SGALDALLCG NGSDAGRCPE GYTCMKAGRN PNYGYTSFDS FGWAFLALFR LMTQDYWENL
     FQLTLRAAGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE EQNQATLAEA REKEEEFQRL
     MEQLKNQENK LGFSDDELSR GDDGDADVKD CNGRIVPRLV IDRVSSDDEL EATEEKCKGF
     KSSMGHLEEP GLKKRSASAV SVLTNAMEEL EETQRPCPPG WYKFADIFLK WDCCTPWIIM
     KKWVHFVVMD PFVDLGITIC IVLNTLFMAM EHYPMSPAFD HMLSVGNLVF TGIFAAEMVF
     KLIAMDPYYY FQVGWNIFDS IIVTLSLVEL GLANVQGLSV LRSFRLLRVF KLAKSWPTLN
     MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK DCVCKIAEDC ELPRWHMNDF
     FHSFLIVFRV LCGEWIETMW DCMEVAGAGM CLVVFMMVMV IGNLVVLNLF LALLLSSFSG
     DNLAGGDDDG EMNNLQIAIG RITRGIDWIK ASIMGLVWKL LGKKAKEGDG GAEEEVQEDL
     SKETFAINHM EAIEAPSADF KMLDGLSHWV DDVHPSGFLL NAEGTLSVPI AKEESDLENP
     DDEEECSSEE EAEQVEKSQS KTPAHAQDDS SECSTVDYRP PEPVLEEVQE EEEPEQQEPE
     ACFTEDCFRR MPCLMVDVTE GKGKTWWNLR KTCFTIVEHG YFETFIIFMI LLSSGALAFE
     DIYIEKRRVI KTILEYADKV FTYVFVVEML LKWVAYGFKV YFTNAWCWLD FLIVDVSLIS
     LTANLLGYSE LGAIKSLRTL RALRPLRALS RFEGMRVVVN ALVGAIPSIF NVLLVCLIFW
     LIFSIMGVNL FAGKFYHCIN TTSEERFPTD VVNNKSDCMA LMHTNEVRWV NVKVNYDNVG
     LGYLSLLQVA TFKGWMDIMY AAVDSREVEE QPSYEENLYM YLYFVIFIIF GSFFTLNLFI
     GVIIDNFNQQ KKKIRGKDIF MTEEQKKYYN AMKKLGSKKP VKPIPRPSKA NLHINYFSNF
     FSFCSFLSPP FYLDAKNKIQ GMVFDFIMQQ FFDIFIMVLI CLNMVTMMVE TDDQSVEKEN
     VLYQINLVFI VIFTCECVLK MFALRQYFFT VGWNIFDFVV VILSVLGIML SDIIEKYFVS
     PTLFRVIRLA RIGRVLRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLIM FIFSIFGMSN
     FAYVKKQAGI DDMFNFETFG NSIICLFEIT TSAGWDGLLL PILNSGPPDC DPSVENPGSD
     VRGNCGNPGV GIVFFCSYII MSFLVVVNMY IAIILENFNV AQEESSDPLC EDDFEMFYET
     WEKFDPEATQ FLEYNKLSDF CDALQEPLRI AKPNRIKLIS MDFPMVTGDK IHCMDILAAL
     TMEVLGDTLE MAAMKVSMET KFMMNNPSKA SFEPIVTTLR HKEEAIAAVV IQRAYRRHLL
     RRCIKQASFT LRSKASTKRE GEDPPETDGM IVRKMKALYG SQALSDEAHL AEPEQLTGPA
     EVETAVTPEA KLFVVPVEVT SDVVLRAAPS RKPSASGGNA RESVV
//
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