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Database: UniProt
Entry: A0A0P7UZM4_9TELE
LinkDB: A0A0P7UZM4_9TELE
Original site: A0A0P7UZM4_9TELE 
ID   A0A0P7UZM4_9TELE        Unreviewed;      1701 AA.
AC   A0A0P7UZM4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   ORFNames=Z043_105069 {ECO:0000313|EMBL:KPP75666.1};
OS   Scleropages formosus (Asian bonytongue).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Osteoglossocephala;
OC   Osteoglossomorpha; Osteoglossiformes; Osteoglossidae; Scleropages.
OX   NCBI_TaxID=113540 {ECO:0000313|EMBL:KPP75666.1, ECO:0000313|Proteomes:UP000034805};
RN   [1] {ECO:0000313|EMBL:KPP75666.1, ECO:0000313|Proteomes:UP000034805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aro1 {ECO:0000313|EMBL:KPP75666.1};
RA   Tan M.H., Gan H.M., Croft L.J., Austin C.M.;
RT   "The genome of the Asian arowana (Scleropages formosus).";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPP75666.1}.
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DR   EMBL; JARO02001375; KPP75666.1; -; Genomic_DNA.
DR   Proteomes; UP000034805; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034805};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034805};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     53     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    478       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    498    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    530    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    703    728       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    782    802       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    814    837       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    905    923       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    993   1017       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1202   1236       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED       86    113       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KPP75666.1}.
SQ   SEQUENCE   1701 AA;  191495 MW;  534A9AE564023AC9 CRC64;
     FNFEEETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVHRGML SSIYFIVLTL
     FGNCILSEYS AILKRARFHT LLNVFLAIAV DNLANAQELT KDEEEQEEAA NKKLALQKAM
     EVKEVSPMSA ANISIAAKEQ QKSLRMMSVW EQRTTQLRRH NMRASNEALY SELDPEERRR
     LSSALHIQPN MNTHLERPLV VEARDGGSXN SSSSNGDGPK AETEWGTPAE PPPNPRKHHR
     RHERLTDEAD VGGEVGDSRD GRRHAHHSRS RDRAGAGERE HRRHHAHHPP KEGNNVLGNG
     GKGEHREPHG EGEVERERRR HHVRSKAQST MDTEECRENG DRVHRHRERH VDKEAEAAPA
     SSQPPHREKQ EDTDNQKNIM RTGQIAVHIP VTVTVPPGET TIISMNKVES DTLQTNEEKK
     ILEDETKDSP QKALPYSSMF VFGPNNPVRR LCHYIVTLRY FEMCILIVIT MSSIALAAED
     PVQANAPRNN VLKYLDYVFT GVFTFEMVIK MIDLGLLLHP GSYFRDLWNI LDFIVVSGAL
     VAFACSGTKG KDINTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VLNILIVYIL
     FMFIFAVIAV QLFKGKFFYC TDESKTLEKD CRGQFLDYDR QDVAAQPREW KKYDFHYDNV
     LWAFLTLFTV STGEGWPMVL KHSVDATYED QGPSPGFRME TSIFYVVYFV VFPFFFVNIF
     VALIIITFQE QGDKAMSECS LEKNERACID FAINAKPLTR YMPENKQSFQ YKMWKFVVST
     PFEYSILTMI ALNTVVLMMK FHGAPDFYEA MLKYLNIVFT ALFSLECILK IIAFGPLNYL
     KDSWNVFDFV TVLGSITDIL VTEIKDKQIN LSVLRLFRAA RLIKLLRQGY TIRILLWTFV
     QSFKALPYVC LLIAMLFFIY AIIGMQVFGN IELNEDTEIN HHNNFRTFFQ ALMLLFRSAT
     GEAWHEIMLS CLSQRPCDEG SGSNGKECGS DFAYFYFVSF IFLCSFLMLN LFVAVIMDNF
     EYLTRDSSIL GPHHLDEFIR VWAEYDPAAC GRIPYMDMYN LLRVISPPLG LGKKCPNRVA
     YKRLVKMNMP IAEDNTVHFT STLMALIRTA LEIKLTSGVL AQRLCDADLK REISNVWPSL
     PQKTIDLLVT PHKPDLALHR ATGRAATLTS SLYLCQHHCL GSPTRGERSV SLSSPRLSPT
     LDNELTVGKV YAALMIFDYY KQNRAKRLQQ QQPGGGTQGK LGVGALFRPV LPLPHIQEQE
     PLPAICVKAE PQVKLEAQRE THPGSPFLNN DTAVQEQGGT SKDSPPRVRE KPQEEQRSRG
     RRILHRDPSE DVPSRPKAQE YLGVTEMELS LVGGGNHAAL ESQGRAASMP KLNAQSQLLP
     SVSSMKRSVS TLAPQRPPEV SLRDYALERQ TPDRTHHHHH HHHHHRCHRR RERDRERDRE
     RERKQRSLDR TAGVQLISGT VASGDLAGGA STRDRTLDRG RSHERKSQPL VSAEKKQRYY
     SCDRYSGREH GQPVFAASRS ASPSGTLEPS LQTQGSGSAR GSLVTLTSGT STPCRGRRQL
     PQTPLTPRPS VAYKTANSSP VPLGAARAGP PTPAIVRPGY GPPERDGEDD RDSSVGSDPS
     QGHRGAPCAR LCHGLPEGVD VFQDALSSQA RRSPRTPGPQ GPLPPRGGVP NGYHFALGVT
     AGPGVIARGP GRHQEKEDDW C
//
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