ID A0A0P7W6H9_9RHOB Unreviewed; 779 AA.
AC A0A0P7W6H9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:KPP85390.1};
GN ORFNames=HLUCCO07_10060 {ECO:0000313|EMBL:KPP85390.1};
OS Rhodobacteraceae bacterium HLUCCO07.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae.
OX NCBI_TaxID=1666914 {ECO:0000313|EMBL:KPP85390.1, ECO:0000313|Proteomes:UP000050369};
RN [1] {ECO:0000313|EMBL:KPP85390.1, ECO:0000313|Proteomes:UP000050369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLUCCO07 {ECO:0000313|EMBL:KPP85390.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPP85390.1}.
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DR EMBL; LJSU01000020; KPP85390.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P7W6H9; -.
DR STRING; 1666914.HLUCCO07_10060; -.
DR PATRIC; fig|1666914.4.peg.3026; -.
DR Proteomes; UP000050369; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 29..309
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 310..584
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 779 AA; 87283 MW; 8909F7E0DE6B1317 CRC64;
MSRFEDEYEV AAAPLSAQAM AGRPAPYLDE LNPAQLEAVE ALDGPVLMLA GAGTGKTKAL
TTRIVHLLNT GKARPNEILS VTFTNKAARE MKERVGRLLG QSIEGMPWMG TFHSICVKLL
RRHAELAGLK SNFTILDTDD QLRLLKQQVA AANIDDKRWP ARQLAGIIDH WKNRAWAPDT
VPASEAGAYN HRGTELYAQY QVRLRELNAV DFGDLLLHMV TIFQRHQDVL EQYQRWFRYI
LVDEYQDTNV AQYLWLRLLA GGHKNICCVG DDDQSIYGWR GAEVGNILRF EKDFPGAKVV
RLEQNYRSTP HILKAASGVI RGNEGRLGKD LWTEAEEGEK VRLIGHWDGE EEARWIGEEI
EALQRGTRGI RPFSLNEMAI LVRASHQMRS FEDRFLTIGL PYRVIGGPRF YERMEIRDAM
AYFRLVVSPG DDLAFERIVN TPKRGLGDVA QQKIQKAARS NGVALSDGAR ILIESKGIGG
KGAVELARLL DGLDRWGRMM GSPELSHVEL AEIILDESGY TQMWQNDKTP EAPGRLENLK
ELVKALESFE NLQGFLEHVS LIMDNDSDEQ DEKVSIMTLH AAKGLEFPAV FLPGWEDGLF
PSQRSMDESG IKGLEEERRL AYVGITRAEE VCTISFAGNR RVYGQWQSQM PSRFIDELPQ
EHVEVLTPPG LYGGGYGAAA SGGVETRAAE ANVYNAPGWR RMQARSKQRP VSQPKETRNQ
VIDLEAISSH TVGERVFHQK FGYGKITGIE GDKLEIEFEK AGVKKVVARF VSGADDIPF
//
