ID A0A0P7XEX0_9BACT Unreviewed; 1441 AA.
AC A0A0P7XEX0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RND-type heavy metal efflux pump permease component CzcA {ECO:0000313|EMBL:KPQ14128.1};
GN Name=czcA {ECO:0000313|EMBL:KPQ14128.1};
GN ORFNames=HLUCCX10_11315 {ECO:0000313|EMBL:KPQ14128.1};
OS Algoriphagus marincola HL-49.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=1305737 {ECO:0000313|EMBL:KPQ14128.1, ECO:0000313|Proteomes:UP000050421};
RN [1] {ECO:0000313|EMBL:KPQ14128.1, ECO:0000313|Proteomes:UP000050421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HL-49 {ECO:0000313|EMBL:KPQ14128.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ14128.1}.
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DR EMBL; LJXT01000071; KPQ14128.1; -; Genomic_DNA.
DR STRING; 1305737.GCA_000526355_01880; -.
DR PATRIC; fig|1305737.6.peg.2876; -.
DR eggNOG; COG3696; Bacteria.
DR OrthoDB; 636130at2; -.
DR Proteomes; UP000050421; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 929..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1441 AA; 160626 MW; 13FA5D45CD99B931 CRC64;
MLDSIIRWSL SHKLIIGIFT FVWIALGIFS LSQLKIGAVP DVTNNQVQVI TTSRNLSTEE
VEKYLTYPVE LEMANLPGVK EIRSISKFGL SVVTIVFEDD MGTYLPRQLI AERLKIAEEN
IPVGFGSPTM GPISTGLGEI YQYIIDVEPG FEEQYSTMDL RTIQDWVVKR QLAGIEGVIE
VNTWGGFLKQ YEVAVNPERL KAMNLALEQV FSAIQSNNSV TGGGYIEKTE ESFFIRGEGL
VKSLEDIRNI VIQSRNGSPI LVSDVADVGF GSASRFGAIT ANGEGEKVLG QIMMLKGADS
KRTIDRVTTR IAEIQKTLPE GVIINGFLDR SELIGRTTST IAENLILGCL IVIFVVVILL
GNLRSGLVVA SVIPLSLFFA LSMMYLFDVD ANLMSLGAID FGIIIDGAVI IVEYIAFRFT
QSGQMLSGLS SHKRREEKDK ISFEGSSKMM RSAIFGQIII ILVFIPVLSL SGVEGKMFRP
MAEVFSFALV GAMILGLTYV PVASSLFLKT KPLGPKNISV RFIGFLNRFY EPALSFALSH
RKLVLITAGI LLLGSIWVFS RMGAEFVPTL DEGDFVIQPV LKTGTTLTNT VETITAIEKI
LKGFPEVNQV VTRIGAAEIP TDPMSMEESD IIVTLHPKDQ WKTVDTKDEL AEEFKKALEI
IPGLDYEFTQ PIEMRFNELI TGVRADLAIK VFGEDLDILL SVATEIESAI QSVDGAADII
LEKVDGLPQM KIDYDRSKIA KYGLNIDQLN DLVNTGFAGK KAGIVFEGEK QFDLVLRFEE
DSRKDIVHLE RLPVRLPNGT FLPLSELANI SYTRGPAKIS RDDTRRRVVI GVNVRNRDLQ
SVVDDIQGII DTRIEIPEGY RVSYGGQFEN LEQARNRLLV AVPVALFLIF IMLYFAFSSV
KDALLIFTAI PFSAIGGILF LWWRDMPFSI SAGIGFIALF GIAVLNGIVL IEYFKSMESK
YSSIKDLVKA GAKDRLRPVF LTASTDALGF LPMALSYSAG AEVQRPLATV VIGGLVSATL
LTLIVLPVLY TIFHGKSFSF NRSVKPLSIT LILMGFIIFP SFGQEKEKLG LEEALSIAIS
QNIDLQASRK MLERSESQVG TGWNIEKTQI SYGWDENDIA ENGVYNRVWR VQQQLEFPSV
YSARSAVLKA ELERSQSEYL LHERQVKKEV STAYLKSFYA RERIYNLVYL DSIYGQFAKA
SARRFELGES NLLEKLTAES KEQELSIRLN AARRDYESSL IELGRLLYLD DSLVLADEEP
LLGLDQNDEI SHPLTMMLEA EIRKADFQVK EARRSFLPEL SMEVFNGSNP GINAQNYPGF
QAGVSIPLFF GSNKSKLNAA SFFQEEIQLQ SQAVTQSLNA RSEQLKNEIS KNRSTLDYYE
EEGLSLAEQL EIQATRSFQE GEIDFLQLVQ LLENSRNIRL QYLQSKLDYQ LAKLELIYLT
I
//
