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Database: UniProt
Entry: A0A0P8AHG2_9RHOB
LinkDB: A0A0P8AHG2_9RHOB
Original site: A0A0P8AHG2_9RHOB 
ID   A0A0P8AHG2_9RHOB        Unreviewed;       497 AA.
AC   A0A0P8AHG2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KPQ17951.1};
GN   ORFNames=HLUCCO18_02765 {ECO:0000313|EMBL:KPQ17951.1};
OS   Rhodobacteraceae bacterium HLUCCO18.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae.
OX   NCBI_TaxID=1666917 {ECO:0000313|EMBL:KPQ17951.1, ECO:0000313|Proteomes:UP000050333};
RN   [1] {ECO:0000313|EMBL:KPQ17951.1, ECO:0000313|Proteomes:UP000050333}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HLUCCO18 {ECO:0000313|EMBL:KPQ17951.1};
RA   Nelson W.C., Romine M.F., Lindemann S.R.;
RT   "Identification and resolution of microdiversity through metagenomic
RT   sequencing of parallel consortia.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPQ17951.1}.
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DR   EMBL; LJSY01000004; KPQ17951.1; -; Genomic_DNA.
DR   EnsemblBacteria; KPQ17951; KPQ17951; HLUCCO18_02765.
DR   PATRIC; fig|1666917.4.peg.445; -.
DR   Proteomes; UP000050333; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050333};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050333}.
FT   DOMAIN      189    321       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      405    474       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     197    204       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   497 AA;  55131 MW;  67BC58E98AF1B2E3 CRC64;
     MTEDTWGQVR NELLKAVGKN NFSAWIAPIS FDRMEGRTAR FHVPTNFFGS WVSQNYGDVI
     RRHLASAGIG ADRVEFHVAP SGAADAGDDD EPRKSAELEA AVAAAPLLAQ SAATNPVAGA
     VADVRPPIRD DTPKAASAPA GAKAPNGKGD VATGSNLNPQ FTFENFVVGK PNELAQAAAR
     RVAEGRDVTF NPLFLYGGVG LGKTHLMHAI AWELQANFPE ADILYLSAEQ FMYRFVRALR
     EQDTIGFKQM FRSVDVLMVD DVQFIAGKTS TQEEFFHTFN ALVEMGKQIV ISGDRAPVDM
     DELDSRIASR LQCGLVVDIH PTDYELRLGV LQHKAERMRE RNPRVQIADG VLEFIARKIS
     SNIRVLEGAL TRLFALADLV QKDITMELAQ DCLADILKHT DKKVTMDEII KKTCEYYNLR
     QSDLMSANRS RAIARPRQIA MFLCKKLTTR SLPEIGRKFG GRDHTTILYG VRKIEELIQV
     DSQIAEDAEI LRRMLEA
//
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