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Database: UniProt
Entry: A0A0P8BCA8_9GAMM
LinkDB: A0A0P8BCA8_9GAMM
Original site: A0A0P8BCA8_9GAMM 
ID   A0A0P8BCA8_9GAMM        Unreviewed;       491 AA.
AC   A0A0P8BCA8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KPQ25811.1};
GN   ORFNames=HLUCCA13_01805 {ECO:0000313|EMBL:KPQ25811.1};
OS   Halomonas sp. HL-48.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1479235 {ECO:0000313|EMBL:KPQ25811.1, ECO:0000313|Proteomes:UP000050569};
RN   [1] {ECO:0000313|EMBL:KPQ25811.1, ECO:0000313|Proteomes:UP000050569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL-48 {ECO:0000313|EMBL:KPQ25811.1};
RA   Nelson W.C., Romine M.F., Lindemann S.R.;
RT   "Identification and resolution of microdiversity through metagenomic
RT   sequencing of parallel consortia.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPQ25811.1}.
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DR   EMBL; LJZS01000002; KPQ25811.1; -; Genomic_DNA.
DR   RefSeq; WP_027337346.1; NZ_KK366039.1.
DR   EnsemblBacteria; KPQ25811; KPQ25811; HLUCCA13_01805.
DR   PATRIC; fig|1479235.4.peg.1158; -.
DR   Proteomes; UP000050569; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050569};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050569}.
FT   DOMAIN      188    379       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      399    468       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     196    203       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   491 AA;  55224 MW;  C2574AE6C20B02D7 CRC64;
     MSLALWQQCL DYLQDELSSQ QFNTWIRPLQ AEDSEANELR LLAPNRFVRD WVSDKYAKRI
     SELMRELSPS KPPKVSLTVG SRRPATPAPQ PRDLGNPVSA SPAPRSSPAV HTPPRGDIAD
     EREIDKLREE GGGNDGRRNN ERQVQVEGSL KHTSGLNPNF TFDTFVEGKS NQLARAASRQ
     VSENPGGAYN PLFLYGGVGL GKTHLMHAVG NALAVRRENA RVVYLHSERF VADMVKALQL
     NAINDFKRFY RSVDALLIDD IQFFAGKERS QEEFFHTFNA LLEGGQQMIL TSDRYPKEIS
     GVEERLKSRF GWGLTVAIEP PELETRVAIL MKKADQAKVD LPHDAAFFIA QKIRSNVREL
     EGALKKVIAD SHFMGKTITQ DFIRESLKDL LALQDKQVGV DNIQRTVAEY YKIKVADLLS
     KRRSRSVARP RQVAMALAKE LTNHSLPEIG DAFGGRDHTT VLHACRKVKS LQEESADIRE
     DYKNLLRLLT S
//
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