ID A0A0P8C575_9BACT Unreviewed; 814 AA.
AC A0A0P8C575;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:KPQ17864.1};
GN Name=wzc {ECO:0000313|EMBL:KPQ17864.1};
GN ORFNames=HLUCCX10_05965 {ECO:0000313|EMBL:KPQ17864.1};
OS Algoriphagus marincola HL-49.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=1305737 {ECO:0000313|EMBL:KPQ17864.1, ECO:0000313|Proteomes:UP000050421};
RN [1] {ECO:0000313|EMBL:KPQ17864.1, ECO:0000313|Proteomes:UP000050421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HL-49 {ECO:0000313|EMBL:KPQ17864.1};
RA Nelson W.C., Romine M.F., Lindemann S.R.;
RT "Identification and resolution of microdiversity through metagenomic
RT sequencing of parallel consortia.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPQ17864.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LJXT01000028; KPQ17864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P8C575; -.
DR STRING; 1305737.GCA_000526355_00757; -.
DR PATRIC; fig|1305737.6.peg.1857; -.
DR eggNOG; COG0489; Bacteria.
DR eggNOG; COG3206; Bacteria.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000050421; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KPQ17864.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 36..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..114
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 459..538
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 611..757
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 814 AA; 92204 MW; 31BFE38EA9B363B5 CRC64;
MYPNSASNPQ NQPNPFLAQQ EDEIDLKVLL FNYLQYWPII VIFMFLGLLS AFLLNKFTTP
IYKVESTVLV VDDKPTLGAD LFESAGLGLQ NKSNIDNEIG ILKSYSLAQS TISEMDLNVA
YFQDDIFKPR QIYGNTPVYV AVDWNREQVV GGLFRLEVLN EQSFELTVED EEAFAVFNPK
DPFYKSKLES FSLPRSVFEF GQEVSGEFYS FTVNLISALP GEVYFFRLID TPSLALKMKD
DLQANPLNKQ ASILTLSMET PLRRLGENYI NKLMEEYLQR ELYEKNQASE NTIRFIEQQL
SGISDSLEYS ESQLQEFRSK NRIFNLSQEG SMIFERLTDL EQERSQIELN LKYLQTLQSY
LDNNQLGDLV APAIVGVTDP LLTSLVESLS ELQADRVRIS ATFNDQTPQM RDINSRIQST
SNALKENVRS AIENSRNTLS DINGRIRLIE QDINALPATE RSLLNYTRQF TINENIYIYL
LQKKAEAEIT MASNMPKNKI LDFAKAGQTP VAPKSSLNLL IGLILGLILP IGFITVKDFL
NTKLEDPKEL EKAIKVPLIS MIGRSNTGDN LPVLLNPRST VTESFRSLRA DMSYLSPNRE
RMTVLFTSSI SGEGKTFVSM NMASVFSLMG KKTILIGLDL RKPKIAEEFG LVNDKGMSTA
LSSDTSWKEI VKSSSYENLD IILSGPIPPN PAELLLQDKF GQIIEEIRQE YDIVVFDCPP
VGIVSETKEL FKHADISFFV FRQGYSMKGN AEVLNNLVEK GGVKKIYGIL NDVHIDKGYG
YGYGYGYGYG YGNNSYGYHE EVQLPWWKRA LRRK
//
