ID A0A0P9ASH9_DROAN Unreviewed; 2430 AA.
AC A0A0P9ASH9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Uncharacterized protein, isoform L {ECO:0000313|EMBL:KPU80359.1};
GN Name=Dana\GF16442 {ECO:0000313|EMBL:KPU80359.1};
GN Synonyms=dana_GLEANR_17712 {ECO:0000313|EMBL:KPU80359.1};
GN ORFNames=GF16442 {ECO:0000313|EMBL:KPU80359.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:KPU80359.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:KPU80359.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; CH902617; KPU80359.1; -; Genomic_DNA.
DR RefSeq; XP_014765959.1; XM_014910473.1.
DR EnsemblMetazoa; FBtr0384880; FBpp0344891; FBgn0093463.
DR GeneID; 6499238; -.
DR OrthoDB; 2909504at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF44; PROTEIN SCRIBBLE HOMOLOG; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 730..817
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 922..1012
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1233..1323
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1330..1422
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 427..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1442..1479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1611..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1661..1843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2087..2142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2159..2198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2346..2430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1442..1472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1712..1843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1904..1949
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2125..2140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2197
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2353..2420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2430 AA; 263646 MW; 25987D46FF97DB53 CRC64;
MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR DLPKNFFRLH
RLRKLGLSDN EINRLPPDIQ NFENLVELDV SRNDIPDIPD DIKHLQSLQV ADFSSNPIPK
LPSGFSQLKN LTVLGLNDMS LTTLPADFGS LTQLESLELR ENLLKHLPET ISQLTKLKRL
DLGDNEIEDL PPYLGYLPGL HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI
SGLVSLTDLD LAQNLLETLP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCV NMQELILTEN
FLSELPPSIG QMTKLSNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKR LPPELGNCTV
LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ PDTDAETGEQ VLSCYLLPQQ
EYQPITPARD LESDSEPFEE REPSRTVVKF SEEATQEKET PFVRQNTPHP KDLKAKAQKL
KVERSRHEDN VNLVTLPEEN GTRLAETPTE TRTIVNNHQQ PAQLVQQPAV GVNSTQPAVG
GVVSPTATVA PPTTIIHSGS DNNNLKATPP AVVATELATT VPADENPEDD EQEDEFESDR
RVGFQVEGED DDFYKRPPKL HRRDTPHHLK NKRVQHLTDK QASEILANAL ASQERNDTTP
QHSLSGKVQS PIEENADAEQ LAVEQEQEEE EQLKRPFDTS LSPIPAGKPE TATEQDNLDG
VTELRLEQYE IHIERTAAGL GLSIAGGKGS TPFKGDDDGI FISRVTEAGP ADLAGLKVGD
KVLKVNGIVV VDADHYQAVQ VLKACGAVLV LVVQREVTRL IGHPVFSEDG SVSQISVETR
PLVAEVPPSA AVSHERYIPA PIEVQPQQQL QQQVPNVQQV APAHTYTGNV FATPSAAQTV
EPSATNGLLN GREAPLSYIQ LHTTLIRDQI GQGLGFSIAG GKGSPPFKDD CDGIFISRIT
EGGLAHRDGK IMVGDRVMAI NGNDMTEAHH DAAVACLTEP QRFVRLVLQR EYRGPLEPPT
SPRSPAVLNS LSPSGYLANR PATFGRAVGG DVEQPYKYNT LATATATPTA TPAGINNNNN
TLPISKTNGF AAAATIDKAT GQPVPAPRRR NSVPLGEQEG APNGAASTAS GDSGEAQPSS
LRPLTSDDFQ AMIPAHFLSG GSQHQVHVAR PNEVGVSAVT VNVNKPQPDL PMFPAAPTEL
GRVTETITKS TFTETVMTRI TDNQLAEPLI SEEVVLPKNQ GSLGFSIIGG TDHSCVPFGT
REPGIFISHI VPGGIASKCG KLRMGDRILK VNEADVSKAT HQDAVLELLK PGDEIKLTIQ
HDPLPPGFQE VLLSKAEGER LGMHIKGGLN GQRGNPADPS DEGVFVSKIN SVGAARRDGR
LKVGMRLLEV NGHSLLGASH QDAVNVLRNA GNEIQLIVCK GYDKSNLIHS IGQAGGMSTG
FNSSASCSGG SRQGSRASET GSELSQSQSV SSLDPDEEER LRQDFDVFAS QKPDAQATSQ
TGLAAAAALV HGAASPTPTS TPIPTPVPVA SADLTASDTP AAQTVALIHA EQAHQQQTQL
APLGQEKSTQ EKVLEIVRAA DAFTTVPPKS PSEHPEQDKI QKTTTVVISK HTLDTNPTTP
TTPAAPLPIA GAESATSGNA PAPAPASAAI VAPASAQVPV PTPAVAVQTQ TQTHETEKDE
EEHQLRSTPA SRHGEEDDEE QATAKATPSK VPKSVSDKKR FFESAMEDQH KPTQKTEKVF
SFLSKDEVEK LRQEEERKIA TLRRDKNSRL LDAANDNIDK DEASRSDKRK DNDANSNSSG
EDNEASDRDS DSARGDAVDN AALGRYEDAD AEDMSAEKRA SWRAARLRSL EQGAVEAQDV
IKNMRKMTDD LITHEAKASE VETCKERIIS LELQVPESEE GTLDDTQPPL ELEGDDFDDN
GAEEDDDFDE EDDEEDDDDE DEEEEEDTAS IVTVQANNEK LFLRHDSDTY GPSSIESSAS
GKVRIKPAPL SLHQTLAKET TIVEVLNPVI GGDGTPRTIH VSGRAPFDGD DYDDESFEQG
AVSVLRSETF VLPAGAGGER SELSLNAKMK TVLEELLENE RVKLNLQKSL EGEEEEEDDE
GSSAYGDARD DVESAYGDAV DDVVDFGRAS NDRDDAKNGN QQLLEELIKD SNRNTIIAKL
AGQLSDDDDE EDDDEEESSD SSEEESDDSD EEDNAEEQLN VTYVQGAQVI ENLNTVAATG
GKLHKSQTYT AIKQAEEEAA KELDMEEDEA VSEPERGPCG SHTLAQLQAE QRALAEISKQ
LRKSVEDLLS ADGGTVVETQ RTYTLPAASD SAAVVTVTEV VKKQKKRKGG SGEAIFNRLL
SGDGAAERQV FDRQQGETVT TTTTTTEAVS PDDNAQPSTS VVTTTTRTVS NVVTSGIPRP
ETSKQGNRNG NGNGNNNNNR NKNKRKGKKK
//
