ID A0A0P9B0D0_9GAMM Unreviewed; 722 AA.
AC A0A0P9B0D0;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:KPU83047.1};
GN ORFNames=JI57_02770 {ECO:0000313|EMBL:KPU83047.1};
OS Psychromonas sp. PRT-SC03.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Psychromonadaceae; Psychromonas.
OX NCBI_TaxID=1527299 {ECO:0000313|EMBL:KPU83047.1, ECO:0000313|Proteomes:UP000053944};
RN [1] {ECO:0000313|EMBL:KPU83047.1, ECO:0000313|Proteomes:UP000053944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PRT-SC03 {ECO:0000313|EMBL:KPU83047.1};
RA Leon Zayas R.I., Novotny M., Podell S., Shepard C.M., Berkenpas E.,
RA Nikolenko S., Pevzner P., Lasken R.S., Bartlett D.H.;
RT "Microbial Metabolic Properties Below 8,000 Meters Depth Within the Puerto
RT Rico Trench Inferred From Single Cell Genomes.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPU83047.1}.
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DR EMBL; JPUQ01000152; KPU83047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0P9B0D0; -.
DR PATRIC; fig|1527299.3.peg.572; -.
DR Proteomes; UP000053944; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000053944}.
FT DOMAIN 8..286
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 287..564
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 722 AA; 83251 MW; 0C0E71F1E189A632 CRC64;
MDVSYLIDGL NDFQRTAVSC PQQNMLVLAG AGSGKTRVLT HRIAWLLEVE HIPTYGILAV
TFTNKAAKEM RARISAICPQ QISGMWIGTF HGIAHRLLRL HFQEANLPEH FQIIDSDDQQ
KMIKRIIKVL NLDDKYYPAK ELQWYINDKK DEGLRAKHID AGYSLQEKQR LQVYKAYEEA
CQLSGLVDFS ELLLRIHELL LTYPALLHHY QQRFKHVLVD EFQDTNKLQY AWLTLLTDAD
NFLTIVGDDD QSIYGWRGAD IENIQRFLKE KDSPVTIRLE QNYRSTGHIL NASNQLIKNN
SDRLDKELWT SGEDGDPIAI YNAFNEYDET RYVIAQIQKW ERDNNKLCDC AILYRSNAQS
RLFEEQLMEN QIPYHIYGGQ RFFDRLEIKD SIAYLRLMNN HQDDAAFERI INKPKRKIGN
TTLDKIRLCA RDQGYTLWHA SCYLIENKLL SAGALRSLEA FIELLTRFKE ETSELPLFQL
MDHIINHSGL KDMFASEKGE KSRSRIENLE ELVSASKSFT IPEEEQDMNE LTDFLAYAAL
ESGDNQADEF ADAVQLMTMH SAKGLEFSQV FMVGVEEGMF PGPRSIEDAT RLAEERRLCY
VGMTRAKKKL TICHADSRRL YGQEKFHNAS RFIAELPEKD IQFIRMKTQV KRAMPNLKPS
FANAPSQDVL GFELGQQVKH VKFGEGTIIA QEGSGENSRL QVHFADVGSK WLMTAYARLE
RI
//
