ID A0A0Q0XKT7_9FLAO Unreviewed; 450 AA.
AC A0A0Q0XKT7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=AAY42_06685 {ECO:0000313|EMBL:KQC29605.1};
OS Allomuricauda eckloniae.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Allomuricauda.
OX NCBI_TaxID=346185 {ECO:0000313|EMBL:KQC29605.1, ECO:0000313|Proteomes:UP000050827};
RN [1] {ECO:0000313|EMBL:KQC29605.1, ECO:0000313|Proteomes:UP000050827}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DK169 {ECO:0000313|EMBL:KQC29605.1,
RC ECO:0000313|Proteomes:UP000050827};
RA Kwon Y.M., Kim S.-J.;
RT "Complete genome of flavobacterium.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQC29605.1}.
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DR EMBL; LCTZ01000002; KQC29605.1; -; Genomic_DNA.
DR RefSeq; WP_055393539.1; NZ_LCTZ01000002.1.
DR AlphaFoldDB; A0A0Q0XKT7; -.
DR STRING; 346185.AAY42_06685; -.
DR PATRIC; fig|1547436.3.peg.1384; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000050827; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000050827};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 133..173
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 450 AA; 49136 MW; 0EE7FFDF23400B31 CRC64;
MSKFELKLPQ MGESVAEATL TTWLKEVGET IELDEAIFEI ATDKVDSEVP SEVEGVLLEK
RFNVDDIIKV GEVVAVIQTD GTEEVTVASN GTDSVDEIED VVEDSAIAIE TEITQVQESV
TASAQDFSST ERFYSPLVKN IAKEEGISMD ELEAIIGTGK EGRVTKNDIK AFLENRSTNG
SITSISKEEN IATVQTETAK ITTENTKAVP VAASADDEII PLTRMGKLIA QHMVDSISTS
AHVQSFVEVD VTNLVNWRNK FKKAFEEREG EKLTFTPIFM EAVATALKKY PLMNISLDGD
KVIKKKNINI GMAAALPDGN LIVPVIKNAD QLNLVGMAKT VNDLANRSRN NQLKPDEVKD
GTYTVTNVGS FGSVFGTPII NQPQVGILAL GAIRKIPSVI ETDQGEYIGI RSKMFLSHSY
DHRVVNGALG GMFVKTVADY LEAWDINREI
//
