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Database: UniProt
Entry: A0A0Q1A5S1_9EURY
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ID   A0A0Q1A5S1_9EURY        Unreviewed;       558 AA.
AC   A0A0Q1A5S1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Adenine deaminase {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
DE            Short=Adenase {ECO:0000256|HAMAP-Rule:MF_01518};
DE            Short=Adenine aminase {ECO:0000256|HAMAP-Rule:MF_01518};
DE            EC=3.5.4.2 {ECO:0000256|ARBA:ARBA00012782, ECO:0000256|HAMAP-Rule:MF_01518};
GN   Name=ade {ECO:0000256|HAMAP-Rule:MF_01518};
GN   ORFNames=APR53_05270 {ECO:0000313|EMBL:KQC03506.1};
OS   Methanoculleus sp. SDB.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX   NCBI_TaxID=1735326 {ECO:0000313|EMBL:KQC03506.1, ECO:0000313|Proteomes:UP000051748};
RN   [1] {ECO:0000313|EMBL:KQC03506.1, ECO:0000313|Proteomes:UP000051748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SDB {ECO:0000313|EMBL:KQC03506.1};
RA   Wawrik B., Marks C.R., Davidova I.A., Mcinerney M.J., Pruitt S., Duncan K.,
RA   Suflita J.M., Callaghan A.V.;
RT   "Metagenomic Analysis of a Methanogenic Paraffin-Utilizing Consortium.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+);
CC         Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000479, ECO:0000256|HAMAP-
CC         Rule:MF_01518};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01518};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenine deaminase family. {ECO:0000256|ARBA:ARBA00006773,
CC       ECO:0000256|HAMAP-Rule:MF_01518}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQC03506.1}.
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DR   EMBL; LKUD01000086; KQC03506.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0Q1A5S1; -.
DR   STRING; 1735326.APR53_05270; -.
DR   Proteomes; UP000051748; Unassembled WGS sequence.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01295; AdeC; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   HAMAP; MF_01518; Adenine_deamin; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR026912; Adenine_deam_C.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01178; ade; 1.
DR   PANTHER; PTHR11113:SF2; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR11113; N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE; 1.
DR   Pfam; PF13382; Adenine_deam_C; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01518};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_01518}.
FT   DOMAIN          65..339
FT                   /note="Amidohydrolase-related"
FT                   /evidence="ECO:0000259|Pfam:PF01979"
FT   DOMAIN          399..545
FT                   /note="Adenine deaminase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13382"
SQ   SEQUENCE   558 AA;  59256 MW;  356C0DEB85DFD825 CRC64;
     MTADALISVA LGERPADLVC HDVSLFNPFS CEWEETSFAV AGGRVAGIGA YEGIREIRFG
     GAQCVPGLID AHVHIESSLL TPVEYGRLVL GHGTTTVVAD PHEIANVAGT DGLDYMLAER
     KKTPLDILLM LPSCVPATPM DRGGATLTAE DLSAYTDREG ILGLGEMMNV PGVLSGDPGV
     AAKMSLCRII DGHAPLLSGH ALNAYIGAGA QSDHECTNLT EAREKLRRGM YIMIREGSTE
     RNLRDLIPLI TPATLSRLCF ATDDRHADML VAEGHIDDCI RKAVGYGCEP EHALRMATLS
     AAERFGLADR GAVAPGRIAD FCILEDGKEF RVARTFRAGV EFRDPGYTRP ASISRPFSCT
     LPVPADLTIT KGGNARVIRL LEHQILTGAE EIGIAPGSIP DTERDILPAV VCDRYRASGF
     GIGLVQGLHL KSGAIASSVS HDSHNIVAAG ADTADILKAV GEVIDHKGGM AAVNGDSIAV
     LPLPCAGLMS DLPYEEVARR IGALEQAVAG MGGIAHPFMY LSFLALTVIP HRRLTERGVF
     DADRFEDISL FSGEDPPP
//
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