ID A0A0Q1FH61_9BACT Unreviewed; 1034 AA.
AC A0A0Q1FH61;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=APR54_06985 {ECO:0000313|EMBL:KQC06604.1};
OS Candidatus Cloacimonas sp. SDB.
OC Bacteria; Candidatus Cloacimonadota; Candidatus Cloacimonadia;
OC Candidatus Cloacimonadales; Candidatus Cloacimonadaceae; Cloacimonas.
OX NCBI_TaxID=1732214 {ECO:0000313|EMBL:KQC06604.1, ECO:0000313|Proteomes:UP000052007};
RN [1] {ECO:0000313|EMBL:KQC06604.1, ECO:0000313|Proteomes:UP000052007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SDB {ECO:0000313|EMBL:KQC06604.1};
RA Wawrik B., Marks C.R., Davidova I.A., Mcinerney M.J., Pruitt S., Duncan K.,
RA Suflita J.M., Callaghan A.V.;
RT "Methanogenic Paraffin-Utilizing Consortium.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQC06604.1}.
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DR EMBL; LKUH01000376; KQC06604.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q1FH61; -.
DR Proteomes; UP000052007; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KQC06604.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KQC06604.1}.
FT DOMAIN 299..488
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 681..1005
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1034 AA; 120303 MW; 45F402ACCEC9A64A CRC64;
MLKKYLKEIA EVFKRGDARE ESYYSSLEKL FIEFSKTQKL KAAITILPKK TEAGNPDFRI
WDGKNHIIGY IEAKAPHQQN LDNIKHSEQL KRYISTFPNV ILTNFLEFIL FRNGVETNRA
QIGRFYHLEQ LGKVPVLENE EKFLDLLEKY FSYKLPKVHT AGSLAKELAK RTRFLKDEVV
RIELDDQHKS NNSILGFYEA FQKYLIKGIT EAEFADLYSQ TITYGLFAAR TRAGDDFNRE
LAFQFIPQTI GILRDVFKFI SLQDPPPALQ VIVDDIAEVL KVTKVNKILK KFYEDGKGKD
PIIHFYETFL SEYDPAMREK RGVYYTPEPV VKYIVRAVHS LLKSRFGLAD GLASENVTLL
DPAGGTLTFP AEAMKLAVQE FTGKYGDGNI QSFLKNHILK NFYSFELMMA PYAIGHLKMG
FLFEELGLHL QDDQRFQLYL TNTLEMEELN VIHIPGLSSL SEESHLAGKV KKQQPILVIM
GNPPYSGISS NSNDWTEKLL KSDLDGAQSY YEVDGQPLGE RNPKWLQDDY VKFLRFAQWK
IQKSGFGIVA MITNHSYLDN PTFRGMRQSL LKTFDEIYLL DLHGNSLKKE TCPDGGKDEN
VFDIRQGVAI AVFVKKKEET EKQVLHADLF GLREKKYGWL EKTDFKLDNY QPLQPASPYY
FLIKRNTKEI QDYLKWPKIT EIFPVNSVGI VTSRDSFTVG PTKNELKLRF SQFTNPNVED
EIIATTYSLK DKTNWKLKQA RTKLKDIDLE EIIKPISYRP FDDRFILYNT NLVERMRFDV
MRHMLEENVG LLSTRFQFKK DISWSCSYIT NYMVDINLIQ SPGTVQILPL YLYPQEDSGD
WHEQLKTERV PNLSAEIVEK FTSNFGKQPT PEEILYYIYA VFYSNIYREK YAEFLKIDFP
RVPFTANYEV FQKMAGLGER VAALHLMKSP ELDKPISRYN GTGENNKIER PVYNEAEKRV
YINNDKYFDN VEPEVWNYMI GGYQVLQKYL KDRKGRQMED SRHYSRIVTT LSKTIEYQKQ
IDEIYEGVEK SIVK
//
