ID A0A0Q2RQY7_MYCGO Unreviewed; 393 AA.
AC A0A0Q2RQY7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KQH77651.1};
GN ORFNames=AO501_33775 {ECO:0000313|EMBL:KQH77651.1};
OS Mycobacterium gordonae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1778 {ECO:0000313|EMBL:KQH77651.1, ECO:0000313|Proteomes:UP000051677};
RN [1] {ECO:0000313|EMBL:KQH77651.1, ECO:0000313|Proteomes:UP000051677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CTRI 14-8773 {ECO:0000313|EMBL:KQH77651.1,
RC ECO:0000313|Proteomes:UP000051677};
RA Ustinova V., Smirnova T., Blagodatskikh K., Varlamov D., Larionova E.,
RA Chernousova L.;
RT "Mycobacterium gordonae draft genome assembly.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQH77651.1}.
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DR EMBL; LKTM01000310; KQH77651.1; -; Genomic_DNA.
DR RefSeq; WP_055579568.1; NZ_LKTM01000310.1.
DR AlphaFoldDB; A0A0Q2RQY7; -.
DR STRING; 1778.A9W97_11635; -.
DR OrthoDB; 9786288at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000051677; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000051677}.
FT DOMAIN 33..235
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 252..388
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 175
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 393 AA; 41725 MW; 89181FED8B97BA9A CRC64;
MSTAAESGIV SPPAAQSAID LAQLPPAPPT TVAVIEAIAT GGPQREVGQT SAAAHVAGLF
ADPEQRERIP RLYQKTRIDS RRMAVDPLDP EFDAFRRSPG TIRERMDLFF DHAVPIAVDT
ARRALAGLPY QTDEIGLLVF VTSTGFVAPG VDVAVVKELG LSRSVSRVVI NFMGCAAAMN
AIRTAATYVR AHPSMKALVV CIELCSVNAV FADDINDVVI HSLFGDGCGA LVIGASQVQQ
PLPAASVVIR SSFSRLLDDA GDGIVLGVNH NGITCELSEN LPDYIYRGVE PVIAEVLRDN
GLAKADIDLW AVHPGGPKII EQSVRSLGIS ADCAAQSWEV LARFGNMLSV SLIFVLEMMV
RQAESAKPIS TGIAFAFAPG VTVEGILFDI IRR
//
