ID A0A0Q3MQU5_AMAAE Unreviewed; 1148 AA.
AC A0A0Q3MQU5;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=3 ubiquitin-protein ligase HECTD3 {ECO:0000313|EMBL:KQK84861.1};
GN ORFNames=AAES_45172 {ECO:0000313|EMBL:KQK84861.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK84861.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK84861.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK84861.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK84861.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMAW01000958; KQK84861.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3MQU5; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd04198; eIF-2B_gamma_N; 1.
DR CDD; cd04652; LbH_eIF2B_gamma_C; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF00632; HECT; 2.
DR Pfam; PF00483; NTP_transferase; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KQK84861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 105..285
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 419..698
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 685
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1148 AA; 130389 MW; 7000E0823681F94E CRC64;
MLKEQLEEYT GSHGLEEGWV LAQRFGGGDK LVPVDSVDKF QWQNQTXGND YKPAARGYTS
LRSQSWEQVV DLTYSMRLGE KPRLVEQDEA AVQKFRSVPP GWSYEHDMEL GRFLYDHSEE
QLQYGDCMTE HVSNIEVSSQ MGDCGAANLM SNQTHSFWES DGPPGQHWVQ LSMKKGSIVK
KLWLVLNGND XSYIPRRVAV YGGPPNRLQH IRTVLINENS FQSVCILRNM KFHLPVLEIR
FLECRDQGYN VRLQGIKIKS FWEWDLILNS XVFQPARLVR YPLLEGVDSS VLYRRAVLIQ
RFVQILDSVL CYLIPLSEDS IGTFNALRNM KPFLLLSKQS TALIAHCLQS SESTPPAILP
KLNINRQLAR EHRANPALDR SYRHTVFTQL YEGLRSSKHN RPLDYRWPTN HTQWWECDFV
TEGIVDNGGG FRDTLSDVSE ELCPSSGNVP VPLPFFVRTS NQGNSSSDTR DMYVPNPSCK
DFPKYEWIGQ LIGAALRSKE FLILALPALV WKQLAGEEID WSKDFAGVDA ELVKLLEMME
GMDREAFEFM FGKELTYTVV RSDQHVVELI PNGSNTVVCY EDRKEFIRLV QKARLEESKE
QIAAMRAGLL CVVPQPVLDL LTWQLMEKKV CGDPKITVSD LRRFEDLSRF LKFVSGRSRL
PVQIIVYPDR SNLDAVDLMP QASTCSCAFF LPSYSSMEFQ AVVMAAGGGS RMTDLTSSIP
KPLLPVGNRP LLWYPLNLLE RAGFEEVIVI TRKEIQKMLN LDTKMKLDFV CISDNMDMGT
ADSLRHIHQK IKTDVLVLSC DLITDVDLYK VVDLFRAHDA TLSMLMKKTH EPTEVVPGQK
GKKKPVEQRD FIGVDDTGKR LLFMANEADL DEELVIKRSI LQKHPRMHIR TGLMDAHLYC
LKKYVVDFLV ENRSITSLRS ELIPHLVRKQ FSSPTSLQQG LDNREEDQKK KEQTSLDIYS
FIKEDNSLLK PAADNSCWND HRGDMNETLH EGKVRCYVHI MKEGLCYXVN TLGLYIEANR
QVRKLLLNLG LEEPLVHGSA QITDRGMVGS DSIIGSSTQV GEKTSIKHSI IGXMCTIKDK
VKITNCIIMN SVTIEEGCCL QGSVICHNAV IEKGADIKDC LIGSDQRLET KAKHVNEVIV
GTEQLMEI
//
