ID   A0A0Q3P994_AMAAE        Unreviewed;       391 AA.
AC   A0A0Q3P994;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|EMBL:KQK77571.1};
GN   ORFNames=AAES_124992 {ECO:0000313|EMBL:KQK77571.1};
OS   Amazona aestiva (Blue-fronted Amazon parrot).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX   NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK77571.1, ECO:0000313|Proteomes:UP000051836};
RN   [1] {ECO:0000313|EMBL:KQK77571.1, ECO:0000313|Proteomes:UP000051836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FVVF132 {ECO:0000313|EMBL:KQK77571.1};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KQK77571.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LMAW01002744; KQK77571.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0Q3P994; -.
DR   STRING; 12930.A0A0Q3P994; -.
DR   Proteomes; UP000051836; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        284..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          12..281
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   391 AA;  43753 MW;  B1252CFC4AD8A551 CRC64;
     MEPEKTAKQT VLITGGGGYF GFRLGCAIYQ KGVDVILFDV MKPLQTVPEG IKFMQGDVRC
     LSEVEEALRD VICVFHIASY GMSGREQLNR KLIEDVNVKG TENVIQACKS TGVSSLVYTS
     TYNVVFGGQI IENGDESLPY LPLHLHPDHY SRTKSLAEMK VLEANGAELG NGKGVLRTCA
     LRPAGIYGPG EQRHLPRIVS YIERGLFKFV YGDPLSLVEF VHVDNLVQAH ILASEALKAN
     KKHIAAGQAY FISDGRPVNN FEFFRPLVEG LGYKFPACRL PLSLVYFFAF LTEVVHFLVG
     HVYNFQPLLT RTEVYKTGVT HYFSMEKARK ELGYEPQQYS LNEVIEWFRS QGCGAKPRKY
     TIIHLVRDGA LLVLVIAVVV SWFLPVITFS L
//