ID A0A0Q3PFT9_AMAAE Unreviewed; 374 AA.
AC A0A0Q3PFT9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Wnt inhibitory factor 1 {ECO:0000256|ARBA:ARBA00013854};
GN ORFNames=AAES_102076 {ECO:0000313|EMBL:KQK79619.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK79619.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK79619.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK79619.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds to WNT proteins and inhibits their activities. May be
CC involved in mesoderm segmentation. {ECO:0000256|ARBA:ARBA00003309}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK79619.1}.
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DR EMBL; LMAW01002576; KQK79619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q3PFT9; -.
DR STRING; 12930.A0A0Q3PFT9; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR InterPro; IPR013309; Wnt-inh.
DR PANTHER; PTHR14949:SF50; 3-PHYTASE; 1.
DR PANTHER; PTHR14949; EGF-LIKE-DOMAIN, MULTIPLE 7, 8; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF21795; JAG1-like_EGF2; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR01901; WIFPROTEIN.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..374
FT /note="Wnt inhibitory factor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006206415"
FT DOMAIN 33..172
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 173..205
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 237..269
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 270..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 302..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 343..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 177..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 195..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 241..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 259..268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 273..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 291..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 305..315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 374 AA; 40813 MW; 08C063002EA3C092 CRC64;
MAPAGRLCAA LLCCALSLCS LRAAPRQPDT LYMWIEAQQA RVLIGFEEDI LIVSEGKMAP
FTHDFRKAQQ RMPAIPVSIH SMNFTWQATG RAEYFYEFLS LHSLDKGIMA DPTINIPLLG
TVPHKASVVQ VGFPCLGKQD GVAAFEVNVI IMNSEGNIIL QTPQNAIFFK TCQQAECPGG
CRNGGVCNER HICECPDGFY GPHCEKALCT PRCMNGGLCI TPGLCICPPG FYGINCDKAN
CTTTCFNGGT CFYLGKCICP SGYEGDQCEI SKCHQPCRNG GKCTGKNKCK CSKGYQGDLC
SKPVCEPSCG LYGTCVEPNK CQCKEGWHGR HCNKRYGASG LSALRPAGSK HRQHTPSPKR
AEERHVPPES NYIW
//
