ID A0A0Q3PJA2_AMAAE Unreviewed; 789 AA.
AC A0A0Q3PJA2;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN ORFNames=AAES_85674 {ECO:0000313|EMBL:KQK81059.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK81059.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK81059.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK81059.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK81059.1}.
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DR EMBL; LMAW01002489; KQK81059.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3PJA2; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000313|EMBL:KQK81059.1};
KW Hydrolase {ECO:0000313|EMBL:KQK81059.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836}.
FT DOMAIN 353..560
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 15..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 87686 MW; D0DE9E3CDFFC4733 CRC64;
MRTYMWKVER NKAKSKWAGG GEEDGEADGE AEDTRESGEE RLSLKTQAFE KFFMQRIELY
DKDEIERKGS ILVDYKDLIQ DKEXTKSIPN ISTELRDMPQ KILQCMGLAI HQVLTKDLER
HAAELQVQEG LPLEGEPIIN VPLIHARVYN YDPLTPLKNV RANCYGKYIA LRGTVVRVSN
IKPLCTXLAF VCGTCGDVQG VPLPDGKYTL PTKCLIPECR GRSFTADRSS SLTTTVDWQS
VKVQELMADD QQEAGRIPRT IECELVQDLV DSCVPGDVVT VTGIVKVSST EEGASRSKND
KCMFLLYIEA NSVSNSKGQK TKSFDDETFQ RSFMEFSLKD LYAVQEIQAE ENLFRLIVNS
LCPAIXGHEI VKAGLALALF GGCQKFVDDK NRIPVRGDPH VLVVGDPGLG KSQMLQAVCN
VAPRGVYVCG NTSTSSGLTV TLSRDGTSGD FALEAGALVL GDQGICGIDE FDKMGNQHQA
LLEAMEQQSI SLAKAGIVCS LPARTSIVAA ANPVGGHYNK AKTVSENLKM GSALLSRFDL
VFILLDTPNE DHDHLLSEHV MAIRAGKKVV CSSAVVTRTN TQDRSILEAP SDRPLLERLK
ILPGENFDAI PHQLLRKYIG YARQYVHPNL SSEAAQVLQE FYLELRKQNQ GADSTPITTR
QLESLIRLTE ARSRLELREK STKEDAEDVI EIMKYSMLGT YSDEFGKLDF ERSQHGSGMS
NRSQAKRFVS ALNSIAERTY NNLFDLQQLR QIAKELQIRV SDFESFIGSL NDQGYLLKKG
SRIYQLQTM
//
