ID A0A0Q3QZJ1_AMAAE Unreviewed; 687 AA.
AC A0A0Q3QZJ1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Frizzled-8 {ECO:0008006|Google:ProtNLM};
GN ORFNames=AAES_113883 {ECO:0000313|EMBL:KQK78577.1};
OS Amazona aestiva (Blue-fronted Amazon parrot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK78577.1, ECO:0000313|Proteomes:UP000051836};
RN [1] {ECO:0000313|EMBL:KQK78577.1, ECO:0000313|Proteomes:UP000051836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FVVF132 {ECO:0000313|EMBL:KQK78577.1};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQK78577.1}.
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DR EMBL; LMAW01002652; KQK78577.1; -; Genomic_DNA.
DR STRING; 12930.A0A0Q3QZJ1; -.
DR Proteomes; UP000051836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07461; CRD_FZ8; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041776; FZ8_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF90; FRIZZLED-8; 1.
DR Pfam; PF01534; Frizzled; 2.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..687
FT /note="Frizzled-8"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006206981"
FT TRANSMEM 260..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..161
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 257..613
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 156..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..206
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 45..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 53..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 90..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 117..158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 121..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 687 AA; 74737 MW; 86B09FBDD2D6D488 CRC64;
MEWSYLLAIT SLLTALSLLQ RPGCAAASAA AAASSSSSSA KELSCQEITV PLCKGIGYNY
TYMPNQFNHD TQDEAGLEVH QFWPLVEIQC SSDLRFFLCS MYTPICLEDY KKPLPPCRSV
CERAKAGCAP LMRQYGFAWP DRMRCDRLPE QGSPDTLCMD YNRTDLTTAA PPPAKPPLRG
AKPGGPAKAP PAAAAPPAEA PRKPRPPPPC EPGCQCRAPM VSVSSERHPL YNRVKTGQIA
NCALPCHNPY FSPDERAFTA FWIGLWSVLC FLSTFATVST FLIDMERFKY PERPIIFLAA
CYLFVSLGYL VRLVAGHEKV ACSGGAXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXLVYFFGMA SSIWWVILSL
TWFLAAGMKW GNEAIAGYAQ YFHLAAWLLP SVKSIAVLAL SSVDGDPVAG ICYVGNQSLE
NLRGFVLAPL LIYLAIGSMF LLAGFVSLFR IRSVIKQQGG PTKTHKLEKL MIRLGLFTVL
YTVPAASVVA CLFYEQHNRP RWEATHNCPC LRDQQPDQAR RPDYAVFMLK YFMCLVVGIT
SGVWVWSGKT LESWRALCTR CCWASKGAAV AGGTGAGGGG QAAIAAAGGL GAGGGGSLYS
DVSTGLTWRS GTASSVSYPK QMPLSQV
//