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Database: UniProt
Entry: A0A0Q3UQ25_AMAAE
LinkDB: A0A0Q3UQ25_AMAAE
Original site: A0A0Q3UQ25_AMAAE 
ID   A0A0Q3UQ25_AMAAE        Unreviewed;      1945 AA.
AC   A0A0Q3UQ25;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=AAES_158784 {ECO:0000313|EMBL:KQK74122.1};
OS   Amazona aestiva (Blue-fronted Amazon parrot).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Amazona.
OX   NCBI_TaxID=12930 {ECO:0000313|EMBL:KQK74122.1, ECO:0000313|Proteomes:UP000051836};
RN   [1] {ECO:0000313|EMBL:KQK74122.1, ECO:0000313|Proteomes:UP000051836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FVVF132 {ECO:0000313|EMBL:KQK74122.1};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQK74122.1}.
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DR   EMBL; LMAW01003082; KQK74122.1; -; Genomic_DNA.
DR   Proteomes; UP000051836; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051836};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KQK74122.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051836};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    259    279       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    353    372       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    392    419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    788    809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    871    896       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    955    977       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1165   1183       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1223       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1235   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1404   1430       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1488   1506       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1518   1536       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1548   1568       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1605   1633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1708   1731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      137    426       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      504    704       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      758    971       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      972   1158       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1163   1438       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1487   1741       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      416    454       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1945 AA;  221718 MW;  C540E308C7145FF0 CRC64;
     MAAKLLAPPG PESFKPFTPE SLANIEKHIA ELKKKQRSKQ DSSHRDDDED SKPKPNSDLE
     AGKNLPFIYG DIPKGLVAVP LEDFDPYYMT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     FRRIAIKILI HSYPFDRLFS MIIMCTILTN CVFMTFSNPP EWSKNVEYTF TGIYTFESLV
     KIIARGFCID GFTFLRDPWN WLDFSVIMMA YVTEFVDLGN VSALRTFRVL RALKTISVIP
     GLKTIVGALI QSVKKLSDVM ILTVFCLSVF ALIGLQLFMG NLRNKCVIWP INVNETFLDN
     GSRGFDWEEY TNNMSNFYII PGAPDPLLCG NSSDAGQCPE GYTCMKAGRN PNYGYTSFDT
     FSWAFLALFR LMTQDFWENL YQLTLRAAGK TYMIFFVLVI FVGSFYLVNL ILAVVAMAYE
     EQNQATLEEA EQKEAEFKAM LEQLKKQQEE AQAAAMVTSA GTVSEDAVED DGGGVRMSRS
     SSELSKLSSK SAKERRNRRK KRKDKELSEG EEKCDTEKVF KSESEDGMRR KAFRLPDNRL
     GRKFSIMNQS LLSIPGSPFL SRHNSKSSIF SYKGRFRDPG SENEFADDEH STVEESEGRR
     DSLFIPIRGR DRRSSYSGYS GYSQGSRSSR IFPNLRRSVK RNSTVDCNGV VSLIGGPPSS
     MPGGRLLPEG TTEIEIRKKP GGSLLVSMDQ VNASYGRKDR TNSVMTGLTN TLVEELEESQ
     RKCPPCWYKF ANTFLIWECH PYWMKLKEIV NLIVMDPFVD LAITICIVLN TLFMAMEHHP
     MTPEFEHVLS VGNLVFTGIF TAEMFLKLIA MDPYYYFQEG WNIFDGFIVS LSLMELGLAD
     VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL
     FGKSYKECVC KINPECELPR WHMHDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLIV
     FMMVMVIGNL VKGIAWIKAK VREFMQAHFK QREADEVKPL DELYDKKVNC IANHTGADIN
     RDIDFQKNGN GTTSGIGSSV EKYIIDEDHM SFINNPNLTV RVPIAVGESD FENHNTEDFS
     SDTDPDGSKE KLDESSSSEG STIDIKPEVE EVPVEAPEEY LDPDACFTEG CTQRCKCCQV
     NIEEGLGXSW WTLRKTCFLI VEHNWFETFI IFMILLSSGA LAFEDIYIEQ RKTIRTILEY
     ADKVFTYIFI LEMLLKWCAY GFVKFFTNAW CWLDFLIVAV SLVSLIANAL GYSELGAIKS
     LRTLRALRPL RALSRFEGMR VVVNALVGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKYH
     YCFNETAEER FEIDIVNNKT DCEALMPPNS TEIRWKNVKI NXDNVGAGYL ALLQVATFKG
     WMDIMYAAVD SRKQEEQPKY EDNIYMYIYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKI
     SQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPLNRIQGAV FDFVTQQAFD IVIMMLICLN
     MVTMMVETDT QSKQMEDILY WINLVFVIFF TCECVLKMFA LRHYYFTIGW NIFDFVVVIL
     SIVGMFLAEI IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG
     LLLFLVMFIF SIFGMSNFAY VKHEAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLLPIL
     NRPPDCDLDK EHPGSGFKGD CGNPSVGIFF FVSYIIISFL IVVNMYIAII LENFSVATEE
     SADPLSEDDF ETFYEIWEKF DPDATQFIEY SKLADFADAL EHPLRVPKPN TIELIAMDLP
     MVSGDRIHCL DILFAFTKRV LGDSGELDIL RQQMEERFVA SNPSKVSYEP ITTTLRRKQE
     EVSAVVIQRA YRARLARRGF ISRRPVSTKL ENGGANREKK EGTPSTASLP SYDSVTKPEK
     EKQQRAEEGR RERAKRPKDV RESKC
//
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