ID A0A0Q4KF81_9SPHN Unreviewed; 501 AA.
AC A0A0Q4KF81;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQN19426.1};
GN ORFNames=ASE86_13205 {ECO:0000313|EMBL:KQN19426.1};
OS Sphingomonas sp. Leaf33.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1736215 {ECO:0000313|EMBL:KQN19426.1, ECO:0000313|Proteomes:UP000051455};
RN [1] {ECO:0000313|EMBL:KQN19426.1, ECO:0000313|Proteomes:UP000051455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf33 {ECO:0000313|EMBL:KQN19426.1,
RC ECO:0000313|Proteomes:UP000051455};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQN19426.1, ECO:0000313|Proteomes:UP000051455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf33 {ECO:0000313|EMBL:KQN19426.1,
RC ECO:0000313|Proteomes:UP000051455};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQN19426.1}.
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DR EMBL; LMLB01000017; KQN19426.1; -; Genomic_DNA.
DR RefSeq; WP_056428508.1; NZ_LMLB01000017.1.
DR AlphaFoldDB; A0A0Q4KF81; -.
DR STRING; 1736215.ASE86_13205; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000051455; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000051455}.
FT ACT_SITE 78
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 13..16
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 78
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 334
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 343
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 347
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 501 AA; 54196 MW; B1DC5B791D81F228 CRC64;
MPDAIGSILI AGGGTAGWMT AAALAHALPR GCTITLVESE EIGTVGVGEA TIPPIRLFNE
TLGIAEGDFL KATKGSFKLG IEFVGWGRAD ARYFHPFGTF GKPFDLIAVH QHWLAARAQG
STVPLDDLSM AWGAASRGRF AAPHADPRSV ASTFDYAYHF DAGLYARFLR DYAEARGVVR
VEGRIADVAR DGESGDVAAI TLADGRRLAA DLFVDCSGFR GLLIEGALAT GYEDWTHWLP
CDRAVAVPCA TGGDGLTPYT RSTARAAGWQ WRIPLQHRTG NGYVFSSAHL SDDDAAATLM
ANLDGPALGE PRFLRFVTGR RRQFWNRNVV AIGLASGFME PLESTSIHLI QAGIAKLLAF
FPTRERDPTA VAEYNRVAIA EFERIRDFLI LHYKLNAGRS ERLWQDCTAM DVPDSLAVKI
EHFRQRGRLV QRENDLFGPA SWLAVHIGQG NVPKSGDPLL AHIADPRASR AFVDKLAGAI
AGMGASMPTH SDWIARTIAT A
//
