ID A0A0Q4KSG7_9SPHN Unreviewed; 501 AA.
AC A0A0Q4KSG7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KQN27464.1};
GN ORFNames=ASF00_14345 {ECO:0000313|EMBL:KQN27464.1};
OS Sphingomonas sp. Leaf34.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1736216 {ECO:0000313|EMBL:KQN27464.1, ECO:0000313|Proteomes:UP000051932};
RN [1] {ECO:0000313|EMBL:KQN27464.1, ECO:0000313|Proteomes:UP000051932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf34 {ECO:0000313|EMBL:KQN27464.1,
RC ECO:0000313|Proteomes:UP000051932};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQN27464.1, ECO:0000313|Proteomes:UP000051932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf34 {ECO:0000313|EMBL:KQN27464.1,
RC ECO:0000313|Proteomes:UP000051932};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQN27464.1}.
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DR EMBL; LMLC01000004; KQN27464.1; -; Genomic_DNA.
DR RefSeq; WP_055880389.1; NZ_LMLC01000004.1.
DR AlphaFoldDB; A0A0Q4KSG7; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000051932; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 328
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 341
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 501 AA; 55211 MW; 41798A22651577B4 CRC64;
MTEQRVKKVV IAGGGTAGWL AAAALSRQLG QLLDITLVES DEIGTIGVGE ATIPTMRSFH
AILGLDERKF MRETQATFKL GISFENWARD GDRYIHSFGD LGKSTWMGDF HHFWLAAKAA
GDPSEIGDYC LELQAAKAER FALPSEGEIH YAYHLDAGLY ARFLRARSEA NGLKRIEGRI
ASVDRDGETG FIRALVLDSG ERVEGDLFID CTGFRGLLIE GTYAAGYEDW SHWLPTNSAL
AVQSAATGPA HPYTRAIAHD AGWRWRIPLQ HRVGNGLVYA SDHLSDDEAH ARLLSAIDGA
PLTEPRLIRF RTGRRRQVWM GNCVALSLAS GFVEPLESTS IHLVMTGVTR LMQAFPFGGI
APAAVTRFNE QAQAELERVR DFIVLHYHLN ERTEPFWAAR RDMPIPATLV ERIALFAEAA
QAYQGGEDLF RVASWVQVML GQRLAPRDHH RLGSIMGGAQ LAGVLTNIRS TIADAVAGMP
MHQQFLDRYL PAPAVSAAQI R
//
