ID A0A0Q4L334_9SPHN Unreviewed; 772 AA.
AC A0A0Q4L334;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KQN28469.1};
GN ORFNames=ASF00_08940 {ECO:0000313|EMBL:KQN28469.1};
OS Sphingomonas sp. Leaf34.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1736216 {ECO:0000313|EMBL:KQN28469.1, ECO:0000313|Proteomes:UP000051932};
RN [1] {ECO:0000313|EMBL:KQN28469.1, ECO:0000313|Proteomes:UP000051932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf34 {ECO:0000313|EMBL:KQN28469.1,
RC ECO:0000313|Proteomes:UP000051932};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQN28469.1, ECO:0000313|Proteomes:UP000051932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf34 {ECO:0000313|EMBL:KQN28469.1,
RC ECO:0000313|Proteomes:UP000051932};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQN28469.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMLC01000003; KQN28469.1; -; Genomic_DNA.
DR RefSeq; WP_055878714.1; NZ_LMLC01000003.1.
DR AlphaFoldDB; A0A0Q4L334; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000051932; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 7..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 193..294
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 346..395
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 772 AA; 82574 MW; DE34ED41EB511267 CRC64;
MVDQVKKVCV IGAGVMGAGI AAQVANAGIP VLLLDIVPRE GDDRDAVAKG AVAKMLKTDP
APFMSKRAAK LVETGNIDDH LDRVAECDWI VEAIVERLDI KQALYAKLEA LKRPGTAVSS
NTSTIPLGNL VAGRTDQFKA DFLITHFFNP PRYMRLVEIV RGAHTDVAVA EKVEDFVDRF
MGKRIVRAKD TPGFIANRIG TYWLAIAINA AMDQGLTVEE ADQIGGRPMG VPKTGIFGLV
DLVGVDLMPL LSKSLSSTLP AGDPYFDTVR DMPLVDKMIA EGFTGRKGKG GFYRFDKATR
TKLSLDLATG EYRPEAKPAE LPGKTGKDLA ALIAEPGKIG TYAWTILGNT LSYAAMLVGE
AADDVVAIDD AMKLGYNWKY GPFELIDRMG PGVLAARLAD EGRDVPAILT TAGDRPFYRV
ENGQRQYLTT GGDYADVPRA DGVELLEDIK LRSQPILQNL SASLWDVGDG VAALEFHTKM
NALDDQVVAL INEAIPVVRE RFKALVVYNE AANFSAGANL GAAMFAVGAG LWDMVEASVK
GGQQAYKALK YAPFPVVSAP AGLALGGGCE VLLHSDAVQA HAETYAGLVE CGVGLVPGWG
GNGEMLDRWT KSGTLPKGPM PVLTKVFQAV STAQVAKSAA EAKEMMILRK DDGITMNRDR
LLADAKAKAL ALVEGYVAPE APTFRLAGAS GRTGLNMAVA DFHKKGMATE YDLVVADRLA
EVLTGGDADL VDTVTEDRLL DLERAAFMAS VKDPRTQARV VHMLQTGKPL RN
//
