ID A0A0Q4MJ14_9GAMM Unreviewed; 235 AA.
AC A0A0Q4MJ14;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN ORFNames=ASF13_10855 {ECO:0000313|EMBL:KQN55176.1};
OS Erwinia sp. Leaf53.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Erwinia.
OX NCBI_TaxID=1736225 {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856};
RN [1] {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf53 {ECO:0000313|EMBL:KQN55176.1,
RC ECO:0000313|Proteomes:UP000050856};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Leaf53 {ECO:0000313|EMBL:KQN55176.1,
RC ECO:0000313|Proteomes:UP000050856};
RA Schulze-Lefert P.;
RT "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).
CC Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive
CC for reinititation, a process called regulatory inhibition of DnaA or
CC RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC the DNA-loaded beta sliding clamp (dnaN). {ECO:0000256|HAMAP-
CC Rule:MF_01158}.
CC -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01158}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KQN55176.1}.
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DR EMBL; LMLK01000023; KQN55176.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0Q4MJ14; -.
DR STRING; 1736225.ASF13_10855; -.
DR Proteomes; UP000050856; Unassembled WGS sequence.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0032297; P:negative regulation of DNA-templated DNA replication initiation; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01158; Hda; 1.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR017788; Hda.
DR InterPro; IPR022864; Hda_Enterobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03420; DnaA_homol_Hda; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF5; DNAA REGULATORY INACTIVATOR HDA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR PRINTS; PR00051; DNAA.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_01158};
KW DNA replication inhibitor {ECO:0000256|ARBA:ARBA00022880,
KW ECO:0000256|HAMAP-Rule:MF_01158};
KW Reference proteome {ECO:0000313|Proteomes:UP000050856}.
FT DOMAIN 19..214
FT /note="Chromosomal replication initiator protein DnaA"
FT /evidence="ECO:0000259|Pfam:PF00308"
SQ SEQUENCE 235 AA; 26627 MW; F81371E3560FB7FF CRC64;
MILNTPAQLS LPLYLPDDET FASFWPGENP SLLAALQGAL HQEHGSYLYF WSRQGGGRSH
LLHAACAELS AKGEAVGYVP LDKRTWFVPE VLDGMEQLAL VCIDNIECIA GDQPWEMAIF
DLYNRILETG KTRLLITGDR PPRQLNLQLP DLASRLDWGQ IYKLQPLSDD DKLQALQLRA
RLRGFELPED VGRFLLKRLD REMRTLFVTL DQLDRASISA QRKLTIPFVK EALAL
//
