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Database: UniProt
Entry: A0A0Q4MJ14_9GAMM
LinkDB: A0A0Q4MJ14_9GAMM
Original site: A0A0Q4MJ14_9GAMM 
ID   A0A0Q4MJ14_9GAMM        Unreviewed;       235 AA.
AC   A0A0Q4MJ14;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 14.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN   Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN   ORFNames=ASF13_10855 {ECO:0000313|EMBL:KQN55176.1};
OS   Erwinia sp. Leaf53.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=1736225 {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856};
RN   [1] {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf53 {ECO:0000313|EMBL:KQN55176.1,
RC   ECO:0000313|Proteomes:UP000050856};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KQN55176.1, ECO:0000313|Proteomes:UP000050856}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Leaf53 {ECO:0000313|EMBL:KQN55176.1,
RC   ECO:0000313|Proteomes:UP000050856};
RA   Vorholt J.;
RT   "Functional overlap of the Arabidopsis leaf and root microbiotas.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinititation, a process called regulatory
CC       inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000256|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KQN55176.1}.
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DR   EMBL; LMLK01000023; KQN55176.1; -; Genomic_DNA.
DR   RefSeq; WP_056239710.1; NZ_LMLK01000023.1.
DR   EnsemblBacteria; KQN55176; KQN55176; ASF13_10855.
DR   Proteomes; UP000050856; Unassembled WGS sequence.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-HAMAP.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050856};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634466};
KW   DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW   ECO:0000256|SAAS:SAAS00634468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050856}.
FT   DOMAIN       19    214       Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
SQ   SEQUENCE   235 AA;  26627 MW;  F81371E3560FB7FF CRC64;
     MILNTPAQLS LPLYLPDDET FASFWPGENP SLLAALQGAL HQEHGSYLYF WSRQGGGRSH
     LLHAACAELS AKGEAVGYVP LDKRTWFVPE VLDGMEQLAL VCIDNIECIA GDQPWEMAIF
     DLYNRILETG KTRLLITGDR PPRQLNLQLP DLASRLDWGQ IYKLQPLSDD DKLQALQLRA
     RLRGFELPED VGRFLLKRLD REMRTLFVTL DQLDRASISA QRKLTIPFVK EALAL
//
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